Characteristics of Hepatocellular Carcinoma in a High Arsenicism Area in Taiwan: A Case-Control Study

Sheng Nan Lu, Nan Haw Chow, Wen Chih Wu, Ting Tsung Chang, Wu Shuang Huang, Shinn Cherng Chen, Chien Hung Lin, Brian I. Carr

Research output: Contribution to journalArticlepeer-review


Arsenic contamination of drinking water is noticeably linked to the occurrence of skin, bladder, lung cancers, and hepatocellular carcinoma (HCC). Blackfoot disease (BFD) caused by arsenicosis is endemic in southwestern Taiwan, where artesian well water contains high concentrations of arsenic, and mortality from HCC shows a dose-response increase by concentration of arsenic in the well water. This case-control study was conducted to examine the clinical characteristics of HCC patients of BFD-endemic area. A total of 65 HCC cases (54 men and 11 women) were recruited from the BFD-endemic areas. The clinicopathological features were compared with 130 age- and sex-matched HCC control patients from non-BFD-endemic areas. Characteristics analyzed included hepatitis viral infection status, hepatitis activity, liver function, histological findings, computed tomography scan characteristics, and patient survival. No differences were observed between HCC patients or their tumors, from study and control areas.

Original languageEnglish
Pages (from-to)437-441
Number of pages5
JournalJournal of Occupational and Environmental Medicine
Issue number5
Publication statusPublished - May 2004

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


Dive into the research topics of 'Characteristics of Hepatocellular Carcinoma in a High Arsenicism Area in Taiwan: A Case-Control Study'. Together they form a unique fingerprint.

Cite this