Characteristics of patients with allergic polysensitization: The polismail study

G. Ciprandi, R. Alesina, R. Ariano, P. Aurnia, P. Borrelli, G. Cadario, A. Capristo, A. Carosso, G. Casino, G. Castiglioni, P. Cesinaro Di Rocco, C. Colangelo, M. Di Gioacchino, M. G. Di Paola, G. Errico, A. Fiorina, F. Gambuzza, S. Gangemi, A. Gasparini, R. GiugnoE. Iemoli, S. Isola, G. Maniero, F. Marengo, P. Mazzali, M. Minelli, M. Mosca, R. Pellegrino, S. Piconi, V. Pravettoni, L. Quaglio, L. Ricciardi, E. Ridolo, V. Sillano, C. Valle, E. Varin, M. Verini, M. Zambito, G. G. Riario-Sforza, C. Incorvaia, P. Puccinelli, S. Scurati, F. Frati

Research output: Contribution to journalArticle

Abstract

Background: The natural history of respiratory allergy is commonly characterized by a worsening of symptom severity, frequent comorbidity of rhinitis and asthma, and polysensitization to aeroallergens. The polysensitization phenomenon starts since childhood and is rare to find monosensitized adult patients. However, there are few studies investigating the characteristics of polysensitized patients. Methods: This study was performed on a large cohort of patients with allergic rhinitis (assessed by ARIA criteria) and/or mild to moderate asthma (assessed by GINA). The kind and the number of sensitizations, their patterns, and the relation with quality of life (QoL) measured by the Juniper's RQLQ questionnaire, were evaluated. Results: Globally 418 patients (50.2% males, 49.8% females, mean age 26.4 years, range 3.5-65 years, 64 smokers, 371 non-smokers) were enrolled: 220 had allergic rhinitis alone, and 198 allergic rhinitis and asthma. The mean number of sensitizations was 2.6. Three hundred-five patients (73%) had persistent rhinitis (PER), 220 of them with moderate-severe form. There was no significant difference in rate of rhinitis and asthma in monosensitized or polysensitized patients. Most patients were sensitized to pollens, whereas only 24.2% of them were sensitized to perennial allergens. Polysensitization was significantly associated with some issues of QoL, confirming previous findings, but not with number of sensitizations. Conclusions: This study provides data confirming for polysensitized patients the relevance of ARIA classification of AR. PER is the most common form of AR in this cohort, symptoms are frequently moderate-severe, and asthma is present in about the half of patients with AR.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalEuropean Annals of Allergy and Clinical Immunology
Volume40
Issue number3
Publication statusPublished - Nov 2008

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Rhinitis
Asthma
Quality of Life
Juniperus
Pollen
Allergens
Comorbidity
Hypersensitivity
Allergic Rhinitis

Keywords

  • Asthma
  • Polysensitization
  • Quality of life
  • Rhinitis

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Ciprandi, G., Alesina, R., Ariano, R., Aurnia, P., Borrelli, P., Cadario, G., ... Frati, F. (2008). Characteristics of patients with allergic polysensitization: The polismail study. European Annals of Allergy and Clinical Immunology, 40(3), 77-83.

Characteristics of patients with allergic polysensitization : The polismail study. / Ciprandi, G.; Alesina, R.; Ariano, R.; Aurnia, P.; Borrelli, P.; Cadario, G.; Capristo, A.; Carosso, A.; Casino, G.; Castiglioni, G.; Di Rocco, P. Cesinaro; Colangelo, C.; Di Gioacchino, M.; Di Paola, M. G.; Errico, G.; Fiorina, A.; Gambuzza, F.; Gangemi, S.; Gasparini, A.; Giugno, R.; Iemoli, E.; Isola, S.; Maniero, G.; Marengo, F.; Mazzali, P.; Minelli, M.; Mosca, M.; Pellegrino, R.; Piconi, S.; Pravettoni, V.; Quaglio, L.; Ricciardi, L.; Ridolo, E.; Sillano, V.; Valle, C.; Varin, E.; Verini, M.; Zambito, M.; Riario-Sforza, G. G.; Incorvaia, C.; Puccinelli, P.; Scurati, S.; Frati, F.

In: European Annals of Allergy and Clinical Immunology, Vol. 40, No. 3, 11.2008, p. 77-83.

Research output: Contribution to journalArticle

Ciprandi, G, Alesina, R, Ariano, R, Aurnia, P, Borrelli, P, Cadario, G, Capristo, A, Carosso, A, Casino, G, Castiglioni, G, Di Rocco, PC, Colangelo, C, Di Gioacchino, M, Di Paola, MG, Errico, G, Fiorina, A, Gambuzza, F, Gangemi, S, Gasparini, A, Giugno, R, Iemoli, E, Isola, S, Maniero, G, Marengo, F, Mazzali, P, Minelli, M, Mosca, M, Pellegrino, R, Piconi, S, Pravettoni, V, Quaglio, L, Ricciardi, L, Ridolo, E, Sillano, V, Valle, C, Varin, E, Verini, M, Zambito, M, Riario-Sforza, GG, Incorvaia, C, Puccinelli, P, Scurati, S & Frati, F 2008, 'Characteristics of patients with allergic polysensitization: The polismail study', European Annals of Allergy and Clinical Immunology, vol. 40, no. 3, pp. 77-83.
Ciprandi G, Alesina R, Ariano R, Aurnia P, Borrelli P, Cadario G et al. Characteristics of patients with allergic polysensitization: The polismail study. European Annals of Allergy and Clinical Immunology. 2008 Nov;40(3):77-83.
Ciprandi, G. ; Alesina, R. ; Ariano, R. ; Aurnia, P. ; Borrelli, P. ; Cadario, G. ; Capristo, A. ; Carosso, A. ; Casino, G. ; Castiglioni, G. ; Di Rocco, P. Cesinaro ; Colangelo, C. ; Di Gioacchino, M. ; Di Paola, M. G. ; Errico, G. ; Fiorina, A. ; Gambuzza, F. ; Gangemi, S. ; Gasparini, A. ; Giugno, R. ; Iemoli, E. ; Isola, S. ; Maniero, G. ; Marengo, F. ; Mazzali, P. ; Minelli, M. ; Mosca, M. ; Pellegrino, R. ; Piconi, S. ; Pravettoni, V. ; Quaglio, L. ; Ricciardi, L. ; Ridolo, E. ; Sillano, V. ; Valle, C. ; Varin, E. ; Verini, M. ; Zambito, M. ; Riario-Sforza, G. G. ; Incorvaia, C. ; Puccinelli, P. ; Scurati, S. ; Frati, F. / Characteristics of patients with allergic polysensitization : The polismail study. In: European Annals of Allergy and Clinical Immunology. 2008 ; Vol. 40, No. 3. pp. 77-83.
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abstract = "Background: The natural history of respiratory allergy is commonly characterized by a worsening of symptom severity, frequent comorbidity of rhinitis and asthma, and polysensitization to aeroallergens. The polysensitization phenomenon starts since childhood and is rare to find monosensitized adult patients. However, there are few studies investigating the characteristics of polysensitized patients. Methods: This study was performed on a large cohort of patients with allergic rhinitis (assessed by ARIA criteria) and/or mild to moderate asthma (assessed by GINA). The kind and the number of sensitizations, their patterns, and the relation with quality of life (QoL) measured by the Juniper's RQLQ questionnaire, were evaluated. Results: Globally 418 patients (50.2{\%} males, 49.8{\%} females, mean age 26.4 years, range 3.5-65 years, 64 smokers, 371 non-smokers) were enrolled: 220 had allergic rhinitis alone, and 198 allergic rhinitis and asthma. The mean number of sensitizations was 2.6. Three hundred-five patients (73{\%}) had persistent rhinitis (PER), 220 of them with moderate-severe form. There was no significant difference in rate of rhinitis and asthma in monosensitized or polysensitized patients. Most patients were sensitized to pollens, whereas only 24.2{\%} of them were sensitized to perennial allergens. Polysensitization was significantly associated with some issues of QoL, confirming previous findings, but not with number of sensitizations. Conclusions: This study provides data confirming for polysensitized patients the relevance of ARIA classification of AR. PER is the most common form of AR in this cohort, symptoms are frequently moderate-severe, and asthma is present in about the half of patients with AR.",
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T1 - Characteristics of patients with allergic polysensitization

T2 - The polismail study

AU - Ciprandi, G.

AU - Alesina, R.

AU - Ariano, R.

AU - Aurnia, P.

AU - Borrelli, P.

AU - Cadario, G.

AU - Capristo, A.

AU - Carosso, A.

AU - Casino, G.

AU - Castiglioni, G.

AU - Di Rocco, P. Cesinaro

AU - Colangelo, C.

AU - Di Gioacchino, M.

AU - Di Paola, M. G.

AU - Errico, G.

AU - Fiorina, A.

AU - Gambuzza, F.

AU - Gangemi, S.

AU - Gasparini, A.

AU - Giugno, R.

AU - Iemoli, E.

AU - Isola, S.

AU - Maniero, G.

AU - Marengo, F.

AU - Mazzali, P.

AU - Minelli, M.

AU - Mosca, M.

AU - Pellegrino, R.

AU - Piconi, S.

AU - Pravettoni, V.

AU - Quaglio, L.

AU - Ricciardi, L.

AU - Ridolo, E.

AU - Sillano, V.

AU - Valle, C.

AU - Varin, E.

AU - Verini, M.

AU - Zambito, M.

AU - Riario-Sforza, G. G.

AU - Incorvaia, C.

AU - Puccinelli, P.

AU - Scurati, S.

AU - Frati, F.

PY - 2008/11

Y1 - 2008/11

N2 - Background: The natural history of respiratory allergy is commonly characterized by a worsening of symptom severity, frequent comorbidity of rhinitis and asthma, and polysensitization to aeroallergens. The polysensitization phenomenon starts since childhood and is rare to find monosensitized adult patients. However, there are few studies investigating the characteristics of polysensitized patients. Methods: This study was performed on a large cohort of patients with allergic rhinitis (assessed by ARIA criteria) and/or mild to moderate asthma (assessed by GINA). The kind and the number of sensitizations, their patterns, and the relation with quality of life (QoL) measured by the Juniper's RQLQ questionnaire, were evaluated. Results: Globally 418 patients (50.2% males, 49.8% females, mean age 26.4 years, range 3.5-65 years, 64 smokers, 371 non-smokers) were enrolled: 220 had allergic rhinitis alone, and 198 allergic rhinitis and asthma. The mean number of sensitizations was 2.6. Three hundred-five patients (73%) had persistent rhinitis (PER), 220 of them with moderate-severe form. There was no significant difference in rate of rhinitis and asthma in monosensitized or polysensitized patients. Most patients were sensitized to pollens, whereas only 24.2% of them were sensitized to perennial allergens. Polysensitization was significantly associated with some issues of QoL, confirming previous findings, but not with number of sensitizations. Conclusions: This study provides data confirming for polysensitized patients the relevance of ARIA classification of AR. PER is the most common form of AR in this cohort, symptoms are frequently moderate-severe, and asthma is present in about the half of patients with AR.

AB - Background: The natural history of respiratory allergy is commonly characterized by a worsening of symptom severity, frequent comorbidity of rhinitis and asthma, and polysensitization to aeroallergens. The polysensitization phenomenon starts since childhood and is rare to find monosensitized adult patients. However, there are few studies investigating the characteristics of polysensitized patients. Methods: This study was performed on a large cohort of patients with allergic rhinitis (assessed by ARIA criteria) and/or mild to moderate asthma (assessed by GINA). The kind and the number of sensitizations, their patterns, and the relation with quality of life (QoL) measured by the Juniper's RQLQ questionnaire, were evaluated. Results: Globally 418 patients (50.2% males, 49.8% females, mean age 26.4 years, range 3.5-65 years, 64 smokers, 371 non-smokers) were enrolled: 220 had allergic rhinitis alone, and 198 allergic rhinitis and asthma. The mean number of sensitizations was 2.6. Three hundred-five patients (73%) had persistent rhinitis (PER), 220 of them with moderate-severe form. There was no significant difference in rate of rhinitis and asthma in monosensitized or polysensitized patients. Most patients were sensitized to pollens, whereas only 24.2% of them were sensitized to perennial allergens. Polysensitization was significantly associated with some issues of QoL, confirming previous findings, but not with number of sensitizations. Conclusions: This study provides data confirming for polysensitized patients the relevance of ARIA classification of AR. PER is the most common form of AR in this cohort, symptoms are frequently moderate-severe, and asthma is present in about the half of patients with AR.

KW - Asthma

KW - Polysensitization

KW - Quality of life

KW - Rhinitis

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