Characteristics of the colorectal cancers diagnosed in the early 2000s in Italy. Figures from the IMPATTO study on colorectal cancer screening

Manuel Zorzi, Lucia Mangone, Emanuela Anghinoni, Susanna Baracco, Elisabetta Borciani, Adele Caldarella, Fabio Falcini, Anna Clara Fanetti, Stefano Ferretti, Paolo Giorgi Rossi, Maria Michiara, Giorgia Randi, Fabrizio Stracci, Massimo Vicentini, Antonella Zucchetto, Marco Zappa, A. Giacomin, A. Azzoni, P. Baldazzi, N. CollinaP. Pandolfi, P. Biavati, G. Gualandi, S. Sciacca, P. Pesce, A. Torrisi, C. Sciacchitano, M. Fidelbo, A. C. Finarelli, C. Naldoni, P. Sassoli De'Bianchi, P. Landi, V. Matarese, A. De Togni, C. Palmonari, E. Crocetti, G. Grazzini, G. Manneschi, P. Mantellini, D. Serraino, E. Bidoli, M. Taborelli, A. Gini, S. Virdone, A. Puppo, C. Casella, M. Celesia, R. Cogno, E. Marani, E. Bugliarello, S. Fattoruso, L. Tamburo, S. Tamburrino, P. Bellardini, M. Autelitano, B. Frammartino, L. Bisanti, S. Ghilardi, R. Leone, R. Corradini, F. De Girolamo, K. Valla, R. Palombino, L. Gigli, S. Russo Spena, M. F. Vitale, M. A. Cascio, R. Mannino, W. Mazzucco, A. Mistretta, B. Ravazzolo, P. Sgarzi, F. Bozzani, M. Zatelli, C. Zurlini, P. Caruana, P. Seghini, G. Gatti, R. Prazzoli, C. Campari, L. Paterlini, T. Cassetti, R. Sassatelli, C. Imolesi, C. Casale, M. Serafini, R. Vattiato, O. Giuliani, R. Cesaraccio, O. Sechi, M. Budroni, A. Madeddu, M. L. Contrino, A. Colanino Ziino, M. Russo, F. Tisano, A. C. Fanetti, S. Maspero, E. Moroni, I. Cometti, M. Gentilini, S. Piffer, G. De Pretis, P. Caciagli, R. Pertile, F. Bianconi, D. Bucchi, M. E. Galeotti, M. Malaspina, A. Greco, A. R. Fiore, C. F. Stocco, C. Fedato

Research output: Contribution to journalReview article

Abstract

The impact of organized screening programmes on colorectal cancer (CRC) can be observed at a population level only several years after the implementation of screening. We compared CRC characteristics by diagnostic modality (screen-detected, non-screen-detected) as an early outcome to monitor screening programme effectiveness. Data on CRCs diagnosed in Italy from 2000 to 2008 were collected by several cancer registries. Linkage with screening datasets made it possible to divide the cases by geographic area, implementation of screening, and modality of diagnosis (screen-detected, non-screen-detected).We compared the main characteristics of the different subgroups of CRCs through multivariate logistic regression models. The study included 23,668 CRCs diagnosed in subjects aged 50-69 years, of which 11.9%were screendetected (N=2,806), all from the North-Centre of Italy. Among screen-detected CRCs, we observed a higher proportion of males, of cases in the distal colon, and a higher mean age of the patients. Compared with pre-screening cases, screen-detected CRCs showed a better distribution by stage at diagnosis (OR for stage III or IV: 0.40, 95%CI: 0.36-0.44) and grading (OR for poorly differentiated CRCs was 0.86, 95%CI: 0.75-1.00). Screen-detected CRCs have more favourable prognostic characteristics than non-screen-detected cases. A renewed effort to implement screening programmes throughout the entire country is recommended.

Original languageEnglish
Pages (from-to)108-114
Number of pages7
JournalEpidemiologia e prevenzione
Volume39
Issue number3
Publication statusPublished - May 1 2015

Keywords

  • Colorectal cancer
  • Colorectal cancer screening
  • Italy

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Fingerprint Dive into the research topics of 'Characteristics of the colorectal cancers diagnosed in the early 2000s in Italy. Figures from the IMPATTO study on colorectal cancer screening'. Together they form a unique fingerprint.

  • Cite this

    Zorzi, M., Mangone, L., Anghinoni, E., Baracco, S., Borciani, E., Caldarella, A., Falcini, F., Fanetti, A. C., Ferretti, S., Rossi, P. G., Michiara, M., Randi, G., Stracci, F., Vicentini, M., Zucchetto, A., Zappa, M., Giacomin, A., Azzoni, A., Baldazzi, P., ... Fedato, C. (2015). Characteristics of the colorectal cancers diagnosed in the early 2000s in Italy. Figures from the IMPATTO study on colorectal cancer screening. Epidemiologia e prevenzione, 39(3), 108-114.