Characteristics, treatment and quality of life of stable coronary artery disease patients with or without angina: Insights from the START study

Leonardo De Luca, Pier Luigi Temporelli, Donata Lucci, Furio Colivicchi, Paolo Calabrò, Carmine Riccio, Antonio Amico, Franco Mascia, Emanuele Proia, Andrea Di Lenarda, Michele Massimo Gulizia

Research output: Contribution to journalArticle

Abstract

Data on contemporary management patterns of angina in patients with stable coronary artery disease (CAD) are scarce. We sought to describe the current presentation, management, and quality of life of stable CAD patients with or without angina, using the data from the START (STable Coronary Artery Diseases RegisTry) study. START was a prospective, observational, nationwide study aimed to evaluate the presentation, management, treatment and quality of life of stable CAD presenting to cardiologists during outpatient visits or discharged from cardiology wards. Among the 5070 consecutive stable CAD patients enrolled in 183 participating centers over a 3-month period, 3714 (73.2%) had no angina and 1356 (26.8%) presented with angina. Patients with angina underwent more frequently coronary angiography (92.7% vs 84.9%; p<0.0001) and other diagnostic imaging procedures compared to those without angina. In addition, patients with angina received more frequently different combinations of first line therapies and angina relief drugs compared to patients without angina. The quality of life, assessed with the EQ 5D-5L questionnaire, did not differ between the two groups, with the exception of the 'pain or worry' domain that was higher in patients with compared to those without angina (p<0.0001). Current management and treatment of stable CAD patients with angina is still suboptimal and different compared to those without angina. Our findings highlight the need for disseminating best-practice patterns and improving guidelines adherence for the management of angina even among cardiologists.

Original languageEnglish
Pages (from-to)e0199770
JournalPLoS One
Volume13
Issue number7
DOIs
Publication statusPublished - 2018

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Stable Angina
quality of life
Registries
Coronary Artery Disease
Quality of Life
Therapeutics
Cardiology
Angiography
Guideline Adherence
coronary artery disease
Diagnostic Imaging
national surveys
Coronary Angiography
Practice Guidelines
Observational Studies
Outpatients
pain
Imaging techniques
questionnaires
Pain

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Characteristics, treatment and quality of life of stable coronary artery disease patients with or without angina : Insights from the START study. / De Luca, Leonardo; Temporelli, Pier Luigi; Lucci, Donata; Colivicchi, Furio; Calabrò, Paolo; Riccio, Carmine; Amico, Antonio; Mascia, Franco; Proia, Emanuele; Di Lenarda, Andrea; Gulizia, Michele Massimo.

In: PLoS One, Vol. 13, No. 7, 2018, p. e0199770.

Research output: Contribution to journalArticle

De Luca, L, Temporelli, PL, Lucci, D, Colivicchi, F, Calabrò, P, Riccio, C, Amico, A, Mascia, F, Proia, E, Di Lenarda, A & Gulizia, MM 2018, 'Characteristics, treatment and quality of life of stable coronary artery disease patients with or without angina: Insights from the START study', PLoS One, vol. 13, no. 7, pp. e0199770. https://doi.org/10.1371/journal.pone.0199770
De Luca, Leonardo ; Temporelli, Pier Luigi ; Lucci, Donata ; Colivicchi, Furio ; Calabrò, Paolo ; Riccio, Carmine ; Amico, Antonio ; Mascia, Franco ; Proia, Emanuele ; Di Lenarda, Andrea ; Gulizia, Michele Massimo. / Characteristics, treatment and quality of life of stable coronary artery disease patients with or without angina : Insights from the START study. In: PLoS One. 2018 ; Vol. 13, No. 7. pp. e0199770.
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