Characterization and degradation behavior of agar-carbomer based hydrogels for drug delivery applications: Solute effect

Filippo Rossi, Marco Santoro, Tommaso Casalini, Pietro Veglianese, Maurizio Masi, Giuseppe Perale

Research output: Contribution to journalArticlepeer-review

Abstract

In this study hydrogels synthesized from agarose and carbomer 974P macromers were selected for their potential application in spinal cord injury (SCI) repair strategies following their ability to carry cells and drugs. Indeed, in drug delivery applications, one of the most important issues to be addressed concerns hydrogel ability to provide a finely controlled delivery of loaded drugs, together with a coherent degradation kinetic. Nevertheless, solute effects on drug delivery system are often neglected in the large body of literature, focusing only on the characterization of unloaded matrices. For this reason, in this work, hydrogels were loaded with a chromophoric salt able to mimic, in terms of steric hindrance, many steroids commonly used in SCI repair, and its effects were investigated both from a structural and a rheological point of view, considering the pH-sensitivity of the material. Additionally, degradation chemistry was assessed by means of infrared bond response (FT-IR) and mass loss.

Original languageEnglish
Pages (from-to)3394-3408
Number of pages15
JournalInternational Journal of Molecular Sciences
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 2011

Keywords

  • Degradation
  • Drug effect
  • FT-IR
  • Hydrogels
  • Rheology

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Medicine(all)

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