Characterization and localization of the TCL-1 oncogene product

T. B. Fu, L. Virgilio, M. G. Narducci, A. Facchiano, G. Russo, C. M. Croce

Research output: Contribution to journalArticlepeer-review

Abstract

The TCL-1 gene maps at chromosome 14q32.1 and is activated in T cell leukemias and lymphomas by either chromosome translocations or inversions that juxtapose the TCL-1 gene to the α/δ or the β locus of the T cell receptor. The open reading frame of the TCL-1 gene, coding for a protein of 114 amino acids, was expressed in bacteria and antisera were raised against it, The antibodies recognized the predicted TCL-1 M(r) 14,000 protein product in cells expressing TCL-1 mRNA. Cell fractionation experiments indicated that the TCL-1 protein is present in the microsomal fraction. These results were confirmed by confocal microscopy. The TCL-1 protein has considerable sequence similarities to the product of the MTCP-1 gene on chromosome Xq28, which is involved in T cell lymphoproliferative diseases. Thus, TCL-1 may represent a member of a novel family of genes involved in lymphoid proliferation and/or survival and in T cell malignancies.

Original languageEnglish
Pages (from-to)6297-6301
Number of pages5
JournalCancer Research
Volume54
Issue number24
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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