Characterization and predicted role of the microRNA expression profile in amnion from obese pregnant women

C. Nardelli, L. Iaffaldano, M. Ferrigno, G. Labruna, G. M. Maruotti, F. Quaglia, V. Capobianco, R. Di Noto, L. Del Vecchio, P. Martinelli, L. Pastore, L. Sacchetti

Research output: Contribution to journalArticlepeer-review

Abstract

Maternal obesity and nutrient excess in utero increase the risk of future metabolic diseases. The mechanisms underlying this process are poorly understood, but probably include genetic, epigenetic alterations and changes in fetal nutrient supply. We have studied the microRNA (miRNA) expression profile in amnion from obese and control women at delivery to investigate if a specific miRNA signature is associated with obesity. The expression profile of 365 human miRNAs was evaluated with the TaqMan Array in amnion from 10 obese and 5 control (prepregnancy body mass index (BMI) >30 and

Original languageEnglish
Pages (from-to)466-469
Number of pages4
JournalInternational Journal of Obesity
Volume38
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • miRNA
  • pathway
  • pregnancy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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