Caratterizzazione e specificita delle crioglobuline in pazienti con epatite cronica C

Translated title of the contribution: Characterization and specificity of cryoglobulins from patients with chronic hepatitis C

A. Cividini, A. Cerino, I. Zorzoli, M. Bissolati, V. Perfetti, A. Ratti, V. Bernini, G. Merlini, M. U. Mondelli

Research output: Contribution to journalArticle

Abstract

Mixed cryoglobulinemia is an immune-complex mediated autoimmune disease frequently associated with chronic HCV infection and underlying lymphoproliferation. We examined the clonality and HCV specificity of immunoglobulins in cryoprecipitates from 27 patients with chronic HCV infection. The results indicate that cryoglobulin recognition of viral polypeptides is both polyclonal and multispecific. Moreover, several IgG3 monoclonal bands were identified which may be responsible for cryoprecipitate formation, as recently reported in the literature.

Original languageItalian
JournalGiornale Italiano di Malattie Infettive
Volume4
Issue numberSUPPL. 1
Publication statusPublished - 1998

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Cryoglobulins
Chronic Hepatitis C
Cryoglobulinemia
Infection
Antigen-Antibody Complex
Autoimmune Diseases
Immunoglobulins
Immunoglobulin G
Peptides

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Caratterizzazione e specificita delle crioglobuline in pazienti con epatite cronica C. / Cividini, A.; Cerino, A.; Zorzoli, I.; Bissolati, M.; Perfetti, V.; Ratti, A.; Bernini, V.; Merlini, G.; Mondelli, M. U.

In: Giornale Italiano di Malattie Infettive, Vol. 4, No. SUPPL. 1, 1998.

Research output: Contribution to journalArticle

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AU - Cividini, A.

AU - Cerino, A.

AU - Zorzoli, I.

AU - Bissolati, M.

AU - Perfetti, V.

AU - Ratti, A.

AU - Bernini, V.

AU - Merlini, G.

AU - Mondelli, M. U.

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KW - Restriction in specificity

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