Characterization of β-adrenergic receptors on human cerebral microvessels

Hideyuki Kobayashi, Lodovico Frattola, Carlo Ferrarese, Pierfranco Spano, Marco Trabucchi

Research output: Contribution to journalArticlepeer-review

Abstract

Cerebral microvessels were separated and prepared from human brain cortex by albumin floatation and glass bead filtration. The binding of a specific β-adrenergic antagonist, (125I) iodohydroxybenzylpindolol, to the microvessel preparation was characterized by high affinity, saturability, and stereospecificity. The presence of specific β-adrenergic receptor sites in human cerebral microvessels sumorts the hypothesis of gdrenergic regulation of the function of cerebral microvessels.

Original languageEnglish
Pages (from-to)1384-1387
Number of pages4
JournalNeurology
Volume32
Issue number12
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

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