Characterization of β-adrenergic receptors on human cerebral microvessels

Hideyuki Kobayashi; Lodovico Frattola; Carlo Ferrarese; Pierfranco Spano; Marco Trabucchi

Characterization of β-adrenergic receptors on human cerebral microvessels

Hideyuki Kobayashi, Lodovico Frattola, Carlo Ferrarese, Pierfranco Spano, Marco Trabucchi

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

Cerebral microvessels were separated and prepared from human brain cortex by albumin floatation and glass bead filtration. The binding of a specific β-adrenergic antagonist, (¹²⁵I) iodohydroxybenzylpindolol, to the microvessel preparation was characterized by high affinity, saturability, and stereospecificity. The presence of specific β-adrenergic receptor sites in human cerebral microvessels sumorts the hypothesis of gdrenergic regulation of the function of cerebral microvessels.

Original language	English
Pages (from-to)	1384-1387
Number of pages	4
Journal	Neurology
Volume	32
Issue number	12
Publication status	Published - 1982

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology
Neuroscience(all)

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title = "Characterization of β-adrenergic receptors on human cerebral microvessels",

abstract = "Cerebral microvessels were separated and prepared from human brain cortex by albumin floatation and glass bead filtration. The binding of a specific β-adrenergic antagonist, (125I) iodohydroxybenzylpindolol, to the microvessel preparation was characterized by high affinity, saturability, and stereospecificity. The presence of specific β-adrenergic receptor sites in human cerebral microvessels sumorts the hypothesis of gdrenergic regulation of the function of cerebral microvessels.",

author = "Hideyuki Kobayashi and Lodovico Frattola and Carlo Ferrarese and Pierfranco Spano and Marco Trabucchi",

year = "1982",

language = "English",

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AU - Frattola, Lodovico

AU - Ferrarese, Carlo

AU - Spano, Pierfranco

AU - Trabucchi, Marco

PY - 1982

Y1 - 1982

N2 - Cerebral microvessels were separated and prepared from human brain cortex by albumin floatation and glass bead filtration. The binding of a specific β-adrenergic antagonist, (125I) iodohydroxybenzylpindolol, to the microvessel preparation was characterized by high affinity, saturability, and stereospecificity. The presence of specific β-adrenergic receptor sites in human cerebral microvessels sumorts the hypothesis of gdrenergic regulation of the function of cerebral microvessels.

AB - Cerebral microvessels were separated and prepared from human brain cortex by albumin floatation and glass bead filtration. The binding of a specific β-adrenergic antagonist, (125I) iodohydroxybenzylpindolol, to the microvessel preparation was characterized by high affinity, saturability, and stereospecificity. The presence of specific β-adrenergic receptor sites in human cerebral microvessels sumorts the hypothesis of gdrenergic regulation of the function of cerebral microvessels.

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