Characterization of 26 Staphylococcus warneri isolates from orthopedic infections

Davide Campoccia, Lucio Montanaro, Livia Visai, Tolmino Corazzari, Claudio Poggio, Francesco Pegreffi, Alessandra Maso, Valter Pirini, Stefano Ravaioli, Ilaria Cangini, Pietro Speziale, Carla Renata Arciola

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Staphylococcus warneri is a coagulase negative Staphylococcus (CNS) commonly present in the flora of human epithelia and mucosal membranes. Over the last two decades, similarly to other CNS species, S. warneri has been reported as a new emerging pathogen, capable of causing serious infections usually in association with the presence of implant materials, but, at times, even in the absence of a foreign body and in patients considered immunocompetent. At present, there is still a lack of scientific data on the pathogenesis and epidemiology of this species. The present study investigated a collection of 26 clinical isolates derived from orthopedic infections, some associated with implant materials and others not. Automated ribotyping showed the existence of 5 distinct ribogroups. Except for the least numerous ribogroup consisting of a single isolate, all other ribogroups included at least one strain obtained from an infection not associated with implant materials, suggesting that putative virulence factors necessary for infections even in the absence of a foreign body could be transversal to most ribogroup categories. Orthopedic infections were found to involve S. warneri strains with low antibiotic resistance potential, differing in this respect from the strains isolated at neonatal intensive care units, where this species has been described to figure among the principal causative agents and exhibit an alarming profile of antibiotic resistance.

Original languageEnglish
Pages (from-to)575-581
Number of pages7
JournalInternational Journal of Artificial Organs
Volume33
Issue number9
Publication statusPublished - Sep 2010

Fingerprint

Orthopedics
Staphylococcus
Coagulase
Antibiotics
Infection
Anti-Bacterial Agents
Intensive care units
Epidemiology
Microbial Drug Resistance
Foreign Bodies
Virulence Factors
Pathogens
Ribotyping
Neonatal Intensive Care Units
Membranes
Epithelium

Keywords

  • Antibiotic resistance
  • Coagulase negative staphylococci
  • Emerging pathogens
  • Orthopedic implant infections
  • Ribotyping
  • Staphylococcus warneri

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

Cite this

Characterization of 26 Staphylococcus warneri isolates from orthopedic infections. / Campoccia, Davide; Montanaro, Lucio; Visai, Livia; Corazzari, Tolmino; Poggio, Claudio; Pegreffi, Francesco; Maso, Alessandra; Pirini, Valter; Ravaioli, Stefano; Cangini, Ilaria; Speziale, Pietro; Arciola, Carla Renata.

In: International Journal of Artificial Organs, Vol. 33, No. 9, 09.2010, p. 575-581.

Research output: Contribution to journalArticle

Campoccia, D, Montanaro, L, Visai, L, Corazzari, T, Poggio, C, Pegreffi, F, Maso, A, Pirini, V, Ravaioli, S, Cangini, I, Speziale, P & Arciola, CR 2010, 'Characterization of 26 Staphylococcus warneri isolates from orthopedic infections', International Journal of Artificial Organs, vol. 33, no. 9, pp. 575-581.
Campoccia, Davide ; Montanaro, Lucio ; Visai, Livia ; Corazzari, Tolmino ; Poggio, Claudio ; Pegreffi, Francesco ; Maso, Alessandra ; Pirini, Valter ; Ravaioli, Stefano ; Cangini, Ilaria ; Speziale, Pietro ; Arciola, Carla Renata. / Characterization of 26 Staphylococcus warneri isolates from orthopedic infections. In: International Journal of Artificial Organs. 2010 ; Vol. 33, No. 9. pp. 575-581.
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