Abstract
Malignant mesotheliomas of the hernial sac are uncommon and only a few cases have been diagnosed incidentally during herniorrhaphy procedures. The prognosis is poor and patient management is difficult because current treatment modalities do little to prolong survival. Molecular markers could be useful to identify potential therapeutic targets. Using microarray-comparative genomic hybridization (aCGH), two cases of peritoneal mesothelioma that were found incidentally at the time of hernia repair, were investigated. A high number of genetic aberrations was detected in both cases. The gains were prevalent. The tumors showed identical lost regions at 2q13, 6q25.3, 6q26, 6q26→q27, 9q31.1→9q31.3, 10p15.3, 11q13.2, 13q14.2, 19q13.42→q43, and gains at 1p36.33, 3q29, 5p15.33, 7p22.3, 10p15.1→10p14, 11q13.2, 12q24.23, 12q24.33, 16p13.3, 17p13.3, 18p11.31, 19q13.43, 21q21.1→q21.2, 22q11.1→q11.22, Xp21.2, Xq28. Survival was longer in the patient with a lower total number of genetic defects. aCGH provides a high-resolution map of copy number changes that may be critical to mesothelioma progression.
| Original language | English |
|---|---|
| Pages (from-to) | 415-421 |
| Number of pages | 7 |
| Journal | Pathology International |
| Volume | 59 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2009 |
Fingerprint
Keywords
- Mesothelioma
- Microarray-comparative genomic hybridization
- Peritoneum
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Characterization of a complex chromosome aberration in two cases of peritoneal mesothelioma arising primarily in the hernial sac. / Serio, Gabriella; Gentile, Mattia; Pennella, Antonio; Marzullo, Andrea; Buonadonna, Antonia Lucia; Nazzaro, Pietro; Testini, Mario; Musti, Marina; Scattone, Anna.
In: Pathology International, Vol. 59, No. 6, 06.2009, p. 415-421.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characterization of a complex chromosome aberration in two cases of peritoneal mesothelioma arising primarily in the hernial sac
AU - Serio, Gabriella
AU - Gentile, Mattia
AU - Pennella, Antonio
AU - Marzullo, Andrea
AU - Buonadonna, Antonia Lucia
AU - Nazzaro, Pietro
AU - Testini, Mario
AU - Musti, Marina
AU - Scattone, Anna
PY - 2009/6
Y1 - 2009/6
N2 - Malignant mesotheliomas of the hernial sac are uncommon and only a few cases have been diagnosed incidentally during herniorrhaphy procedures. The prognosis is poor and patient management is difficult because current treatment modalities do little to prolong survival. Molecular markers could be useful to identify potential therapeutic targets. Using microarray-comparative genomic hybridization (aCGH), two cases of peritoneal mesothelioma that were found incidentally at the time of hernia repair, were investigated. A high number of genetic aberrations was detected in both cases. The gains were prevalent. The tumors showed identical lost regions at 2q13, 6q25.3, 6q26, 6q26→q27, 9q31.1→9q31.3, 10p15.3, 11q13.2, 13q14.2, 19q13.42→q43, and gains at 1p36.33, 3q29, 5p15.33, 7p22.3, 10p15.1→10p14, 11q13.2, 12q24.23, 12q24.33, 16p13.3, 17p13.3, 18p11.31, 19q13.43, 21q21.1→q21.2, 22q11.1→q11.22, Xp21.2, Xq28. Survival was longer in the patient with a lower total number of genetic defects. aCGH provides a high-resolution map of copy number changes that may be critical to mesothelioma progression.
AB - Malignant mesotheliomas of the hernial sac are uncommon and only a few cases have been diagnosed incidentally during herniorrhaphy procedures. The prognosis is poor and patient management is difficult because current treatment modalities do little to prolong survival. Molecular markers could be useful to identify potential therapeutic targets. Using microarray-comparative genomic hybridization (aCGH), two cases of peritoneal mesothelioma that were found incidentally at the time of hernia repair, were investigated. A high number of genetic aberrations was detected in both cases. The gains were prevalent. The tumors showed identical lost regions at 2q13, 6q25.3, 6q26, 6q26→q27, 9q31.1→9q31.3, 10p15.3, 11q13.2, 13q14.2, 19q13.42→q43, and gains at 1p36.33, 3q29, 5p15.33, 7p22.3, 10p15.1→10p14, 11q13.2, 12q24.23, 12q24.33, 16p13.3, 17p13.3, 18p11.31, 19q13.43, 21q21.1→q21.2, 22q11.1→q11.22, Xp21.2, Xq28. Survival was longer in the patient with a lower total number of genetic defects. aCGH provides a high-resolution map of copy number changes that may be critical to mesothelioma progression.
KW - Mesothelioma
KW - Microarray-comparative genomic hybridization
KW - Peritoneum
UR - http://www.scopus.com/inward/record.url?scp=65649140476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65649140476&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1827.2009.02387.x
DO - 10.1111/j.1440-1827.2009.02387.x
M3 - Article
C2 - 19490474
AN - SCOPUS:65649140476
VL - 59
SP - 415
EP - 421
JO - Pathology International
JF - Pathology International
SN - 1320-5463
IS - 6
ER -