TY - JOUR
T1 - Characterization of a new case of trisomy 8 in acute lymphoblastic leukemia
AU - Angioni, Adriano
AU - Ruscio, Carla
AU - Giovannelli, Luigi
AU - Miano, Crescenzo
AU - Rosati, Domenico
AU - Balloni, Pietro
AU - De Laurenzi, Antonio
AU - Mecucci, Cristina
PY - 1994
Y1 - 1994
N2 - Trisomy 8 is a relatively common finding in acute nonlymphoblastic leukemia (ANLL). In childhood acute lymphoblastic leukemia (ALL) it apparently is much more rare. Although Human Gene Mapping 11 included trisomy 8 as a marker for a subgroup of ALL, morphologic and immunologic characteristics of this entity have not been defined. We describe a case of early T-cell ALL (T-ALL) in a pediatric patient in whom this abnormality was the sole chromosome aberration. In situ hybridization with a chromosome 8-specific α-satellite DNA probe was performed. Our data are discussed and compared with pertinent literature.
AB - Trisomy 8 is a relatively common finding in acute nonlymphoblastic leukemia (ANLL). In childhood acute lymphoblastic leukemia (ALL) it apparently is much more rare. Although Human Gene Mapping 11 included trisomy 8 as a marker for a subgroup of ALL, morphologic and immunologic characteristics of this entity have not been defined. We describe a case of early T-cell ALL (T-ALL) in a pediatric patient in whom this abnormality was the sole chromosome aberration. In situ hybridization with a chromosome 8-specific α-satellite DNA probe was performed. Our data are discussed and compared with pertinent literature.
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U2 - 10.1016/0165-4608(94)90013-2
DO - 10.1016/0165-4608(94)90013-2
M3 - Article
C2 - 8019959
AN - SCOPUS:0028339232
VL - 74
SP - 144
EP - 146
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -