Abstract
Trisomy 8 is a relatively common finding in acute nonlymphoblastic leukemia (ANLL). In childhood acute lymphoblastic leukemia (ALL) it apparently is much more rare. Although Human Gene Mapping 11 included trisomy 8 as a marker for a subgroup of ALL, morphologic and immunologic characteristics of this entity have not been defined. We describe a case of early T-cell ALL (T-ALL) in a pediatric patient in whom this abnormality was the sole chromosome aberration. In situ hybridization with a chromosome 8-specific α-satellite DNA probe was performed. Our data are discussed and compared with pertinent literature.
| Original language | English |
|---|---|
| Pages (from-to) | 144-146 |
| Number of pages | 3 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 74 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1994 |
ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
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Angioni, A., Ruscio, C., Giovannelli, L., Miano, C., Rosati, D., Balloni, P., De Laurenzi, A., & Mecucci, C. (1994). Characterization of a new case of trisomy 8 in acute lymphoblastic leukemia. Cancer Genetics and Cytogenetics, 74(2), 144-146. https://doi.org/10.1016/0165-4608(94)90013-2