Characterization of a new case of trisomy 8 in acute lymphoblastic leukemia

Adriano Angioni, Carla Ruscio, Luigi Giovannelli, Crescenzo Miano, Domenico Rosati, Pietro Balloni, Antonio De Laurenzi, Cristina Mecucci

Research output: Contribution to journalArticlepeer-review

Abstract

Trisomy 8 is a relatively common finding in acute nonlymphoblastic leukemia (ANLL). In childhood acute lymphoblastic leukemia (ALL) it apparently is much more rare. Although Human Gene Mapping 11 included trisomy 8 as a marker for a subgroup of ALL, morphologic and immunologic characteristics of this entity have not been defined. We describe a case of early T-cell ALL (T-ALL) in a pediatric patient in whom this abnormality was the sole chromosome aberration. In situ hybridization with a chromosome 8-specific α-satellite DNA probe was performed. Our data are discussed and compared with pertinent literature.

Original languageEnglish
Pages (from-to)144-146
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume74
Issue number2
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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