Characterization of a new extended-spectrum β-lactamase (TEM-87) isolated in Proteus mirabilis during an Italian survey

Mariagrazia Perilli, Bernardetta Segatore, Maria Rosaria De Massis, Nicola Franceschini, Ciro Bianchi, Gian Maria Rossolini, Gianfranco Amicosante

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Abstract

A new natural TEM derivative, named TEM-87, was identified in a Proteus mirabilis isolate from an Italian hospital. Compared to TEM-1, TEM-87 contains the following mutations: E104K, R164C, and M182T. Kinetic analysis of TEM-87 revealed extended-spectrum activity against oxyimino cephalosporins (preferentially ceftazidime) and aztreonam. Expression of blaTEM-87 in Escherichia coli decreased the host susceptibility to these drugs.

Original languageEnglish
Pages (from-to)925-928
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume46
Issue number3
DOIs
Publication statusPublished - 2002

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ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Perilli, M., Segatore, B., De Massis, M. R., Franceschini, N., Bianchi, C., Rossolini, G. M., & Amicosante, G. (2002). Characterization of a new extended-spectrum β-lactamase (TEM-87) isolated in Proteus mirabilis during an Italian survey. Antimicrobial Agents and Chemotherapy, 46(3), 925-928. https://doi.org/10.1128/AAC.46.3.925-928.2002