Characterization of a new HLA-DRB3 allele, DRB3*0217, by direct sequencing

S. Frison, E. Longhi, F. Poli, A. Espadas De Arias, M. Scalamogna

Research output: Contribution to journalArticle

Abstract

We report the identification of a novel DRB3*02 using sequence-based typing (SBT). This new allele, officially named DRB3*0217, was detected while performing HLA high resolution typing of a bone marrow recipient and his siblings. DNA sequencing demonstrated the presence of a nucleotide substitution in exon 2 at position 199 where a C was substituted by a T. This point mutation at codon 67 (CTC→TTC) has resulted in an amino acid substitution from Leucine to Phenylalanine.

Original languageEnglish
Pages (from-to)189-190
Number of pages2
JournalTissue Antigens
Volume60
Issue number2
DOIs
Publication statusPublished - Aug 1 2002

Fingerprint

HLA-DRB3 Chains
Amino Acid Substitution
Phenylalanine
DNA Sequence Analysis
Point Mutation
Codon
Leucine
Exons
Substitution reactions
Nucleotides
Bone Marrow
Alleles
Bone
Amino Acids
DNA

Keywords

  • HLA-DRB3
  • SBT

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Characterization of a new HLA-DRB3 allele, DRB3*0217, by direct sequencing. / Frison, S.; Longhi, E.; Poli, F.; Espadas De Arias, A.; Scalamogna, M.

In: Tissue Antigens, Vol. 60, No. 2, 01.08.2002, p. 189-190.

Research output: Contribution to journalArticle

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