Abstract
We report the identification of a novel DRB3*02 using sequence-based typing (SBT). This new allele, officially named DRB3*0217, was detected while performing HLA high resolution typing of a bone marrow recipient and his siblings. DNA sequencing demonstrated the presence of a nucleotide substitution in exon 2 at position 199 where a C was substituted by a T. This point mutation at codon 67 (CTC→TTC) has resulted in an amino acid substitution from Leucine to Phenylalanine.
| Original language | English |
|---|---|
| Pages (from-to) | 189-190 |
| Number of pages | 2 |
| Journal | Tissue Antigens |
| Volume | 60 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 1 2002 |
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Keywords
- HLA-DRB3
- SBT
ASJC Scopus subject areas
- Cell Biology
- Immunology
Cite this
Characterization of a new HLA-DRB3 allele, DRB3*0217, by direct sequencing. / Frison, S.; Longhi, E.; Poli, F.; Espadas De Arias, A.; Scalamogna, M.
In: Tissue Antigens, Vol. 60, No. 2, 01.08.2002, p. 189-190.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characterization of a new HLA-DRB3 allele, DRB3*0217, by direct sequencing
AU - Frison, S.
AU - Longhi, E.
AU - Poli, F.
AU - Espadas De Arias, A.
AU - Scalamogna, M.
PY - 2002/8/1
Y1 - 2002/8/1
N2 - We report the identification of a novel DRB3*02 using sequence-based typing (SBT). This new allele, officially named DRB3*0217, was detected while performing HLA high resolution typing of a bone marrow recipient and his siblings. DNA sequencing demonstrated the presence of a nucleotide substitution in exon 2 at position 199 where a C was substituted by a T. This point mutation at codon 67 (CTC→TTC) has resulted in an amino acid substitution from Leucine to Phenylalanine.
AB - We report the identification of a novel DRB3*02 using sequence-based typing (SBT). This new allele, officially named DRB3*0217, was detected while performing HLA high resolution typing of a bone marrow recipient and his siblings. DNA sequencing demonstrated the presence of a nucleotide substitution in exon 2 at position 199 where a C was substituted by a T. This point mutation at codon 67 (CTC→TTC) has resulted in an amino acid substitution from Leucine to Phenylalanine.
KW - HLA-DRB3
KW - SBT
UR - http://www.scopus.com/inward/record.url?scp=0036702807&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036702807&partnerID=8YFLogxK
U2 - 10.1034/j.1399-0039.2002.600211.x
DO - 10.1034/j.1399-0039.2002.600211.x
M3 - Article
C2 - 12392515
AN - SCOPUS:0036702807
VL - 60
SP - 189
EP - 190
JO - Tissue Antigens
JF - Tissue Antigens
SN - 0001-2815
IS - 2
ER -