TY - JOUR
T1 - Characterization of a novel putative Xer-dependent integrative mobile element carrying the blaNMC-A carbapenemase gene, inserted into the chromosome of members of the Enterobacter cloacae complex
AU - Antonelli, Alberto
AU - D'Andrea, Marco Maria
AU - Di Pilato, Vincenzo
AU - Viaggi, Bruno
AU - Torricelli, Francesca
AU - Rossolini, Gian Maria
PY - 2015/10/1
Y1 - 2015/10/1
N2 - An Enterobacter ludwigii strain was isolated during routine screening of a Japanese patient for carriage of carbapenem-resistant Enterobacteriaceae. PCR analysis revealed the blaNMC-A carbapenemase gene. Whole-genome sequencing revealed that blaNMC-A was inserted in the chromosome and associated with a novel 29.1-kb putative Xer-dependent integrative mobile element, named EludIMEX-1. Bioinformatic analysis identified similar elements in the genomes of an Enterobacter asburiae strain and of other Enterobacter cloacae complex strains, confirming the mobile nature of this element.
AB - An Enterobacter ludwigii strain was isolated during routine screening of a Japanese patient for carriage of carbapenem-resistant Enterobacteriaceae. PCR analysis revealed the blaNMC-A carbapenemase gene. Whole-genome sequencing revealed that blaNMC-A was inserted in the chromosome and associated with a novel 29.1-kb putative Xer-dependent integrative mobile element, named EludIMEX-1. Bioinformatic analysis identified similar elements in the genomes of an Enterobacter asburiae strain and of other Enterobacter cloacae complex strains, confirming the mobile nature of this element.
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U2 - 10.1128/AAC.01452-15
DO - 10.1128/AAC.01452-15
M3 - Article
AN - SCOPUS:84942899931
VL - 59
SP - 6620
EP - 6624
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 10
ER -