Characterization of anti-streptolysin 0 activity of a human monoclonal IgG lambda

V. Bellotti, F. Pavesi, G. Merlini, I. Zorzoli, V. Perfetti, C. Bergonzi, F. Aguzzi, E. Ascari

Research output: Contribution to journalArticle

Abstract

A human monoclonal component with anti-streptolysin activity (titer 1:15000) was dicovered in a patient with a monoclonal gammopathy of undetermined significance. The antibody activity was determined by a hemolysis inhibition test and immunoblotting using whole immunoglobulin and Fab,F(ab')2 and Fc fragments. The anti-streptolysin activity was found to be located in the Fab-F(ab')2 fragments and directed against a 57 Kd protein with an isoelectric point of 7.5.

Original languageEnglish
Pages (from-to)233-236
Number of pages4
JournalHaematologica
Volume72
Issue number3
Publication statusPublished - 1987

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Streptolysins
Human Activities
Immunoglobulin G
Monoclonal Gammopathy of Undetermined Significance
Immunoglobulin Fc Fragments
Immunoglobulin Fab Fragments
Isoelectric Point
Hemolysis
Immunoblotting
Antibodies
Proteins

ASJC Scopus subject areas

  • Hematology

Cite this

Bellotti, V., Pavesi, F., Merlini, G., Zorzoli, I., Perfetti, V., Bergonzi, C., ... Ascari, E. (1987). Characterization of anti-streptolysin 0 activity of a human monoclonal IgG lambda. Haematologica, 72(3), 233-236.

Characterization of anti-streptolysin 0 activity of a human monoclonal IgG lambda. / Bellotti, V.; Pavesi, F.; Merlini, G.; Zorzoli, I.; Perfetti, V.; Bergonzi, C.; Aguzzi, F.; Ascari, E.

In: Haematologica, Vol. 72, No. 3, 1987, p. 233-236.

Research output: Contribution to journalArticle

Bellotti, V, Pavesi, F, Merlini, G, Zorzoli, I, Perfetti, V, Bergonzi, C, Aguzzi, F & Ascari, E 1987, 'Characterization of anti-streptolysin 0 activity of a human monoclonal IgG lambda', Haematologica, vol. 72, no. 3, pp. 233-236.
Bellotti, V. ; Pavesi, F. ; Merlini, G. ; Zorzoli, I. ; Perfetti, V. ; Bergonzi, C. ; Aguzzi, F. ; Ascari, E. / Characterization of anti-streptolysin 0 activity of a human monoclonal IgG lambda. In: Haematologica. 1987 ; Vol. 72, No. 3. pp. 233-236.
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