A human monoclonal component with anti-streptolysin activity (titer 1:15000) was dicovered in a patient with a monoclonal gammopathy of undetermined significance. The antibody activity was determined by a hemolysis inhibition test and immunoblotting using whole immunoglobulin and Fab,F(ab')2 and Fc fragments. The anti-streptolysin activity was found to be located in the Fab-F(ab')2 fragments and directed against a 57 Kd protein with an isoelectric point of 7.5.
|Number of pages||4|
|Publication status||Published - 1987|
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