Characterization of CD56-/CD16+ natural killer (NK) cells: A highly dysfunctional NK subset expanded in HIV-infected viremic individuals

Domenico Mavilio, Gabriella Lombardo, Janet Benjamin, Diana Kim, Dean Follman, Emanuela Marcenaro, M. Angeline O'Shea, Audrey Kinter, Colin Kovacs, Alessandro Moretta, Anthony S. Fauci

Research output: Contribution to journalArticle

Abstract

Natural killer (NK) cells are an important component of the innate immune response against viral infections. NK cell-mediated cytolytic activity is defective in HIV-infected individuals with high levels of viral replication. In the present study, we examined the phenotypic and functional characteristics of an unusual CD56-/CD16+ (CD56-) NK subset that is greatly expanded in HIV-viremic individuals. The higher level of expression of inhibitory NK receptors and the lower level of expression of natural cytotoxicity receptors observed in the CD56- NK fraction compared with that of CD56+ NK cells was associated with extremely poor in vitro cytotoxic function of this subset. In addition, the secretion of certain cytokines known to be important in initiating antiviral immune responses was markedly reduced in the CD56-, as compared with the CD56+ NK cell subset. These data suggest that the expansion of this highly dysfunctional CD56- NK cell subset in HIV-viremic individuals largely accounts for the impaired function of the total NK cell population.

Original languageEnglish
Pages (from-to)2886-2891
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number8
DOIs
Publication statusPublished - Feb 22 2005

Keywords

  • Cytokines
  • Cytotoxicity
  • Inhibitory NK receptors
  • Killer immunoglobulin-like receptors
  • Natural cytotoxicity receptors

ASJC Scopus subject areas

  • Genetics
  • General

Fingerprint Dive into the research topics of 'Characterization of CD56-/CD16+ natural killer (NK) cells: A highly dysfunctional NK subset expanded in HIV-infected viremic individuals'. Together they form a unique fingerprint.

  • Cite this