Characterization of circadian COPD symptoms by phenotype: Methodology of the STORICO observational study

G W Canonica, F Blasi, N Scichilone, L Simoni, A Zullo, C Giovannetti, C Briguglio, S Barsanti, R Antonelli Incalzi, STORICO study group

Research output: Contribution to journalArticle

Abstract

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. The symptoms of COPD are troublesome, variable, can occur during all parts of the 24-h day and have a substantial impact on patients' health status, quality of life and healthcare resource utilization. Reducing symptoms, improving health status and increasing physical activity are major goals in the management of stable COPD. In order to provide effective, patient-oriented care, patients should be evaluated on the basis of lung function, frequency of symptoms and patient-perceived impact of symptoms on their lives and treatment decisions made on a case-by-case basis. The identification of COPD phenotypes is an evolving debate and literature data about the circadian variation of COPD symptoms according to phenotypes are nowadays lacking. The ongoing STORICO (STudio Osservazionale sulla caratteRizzazione dei sIntomi delle 24 ore nei pazienti con BPCO) study (NCT03105999) is aimed to describe by clinically defined phenotypes the frequency and 12-month evolution of early-morning, day- and night-time COPD symptoms in a cohort of 600 Italian patients with stable COPD. Secondary objectives include the description of the 12-month variation of outcomes of interest according to phenotypes and of the healthcare resources utilization (overall and by phenotype) during 12-month observation. An exploratory analysis will be conducted aimed to phenotype COPD patients in an alternative researcher-independent way based on circadian pattern of symptoms combined with measures of respiratory function, health-related quality of life and comorbidity. The present paper describes the methodology of the STORICO study.

Original languageEnglish
Pages (from-to)62-68
Number of pages7
JournalEuropean Journal of Internal Medicine
Volume43
DOIs
Publication statusPublished - Sep 2017

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Chronic Obstructive Pulmonary Disease
Observational Studies
Phenotype
Health Status
Quality of Life
Quality of Health Care
Comorbidity
Patient Care
Research Personnel
Observation
Exercise
Morbidity
Delivery of Health Care
Lung
Mortality

Keywords

  • Journal Article

Cite this

Characterization of circadian COPD symptoms by phenotype: Methodology of the STORICO observational study. / Canonica, G W; Blasi, F; Scichilone, N; Simoni, L; Zullo, A; Giovannetti, C; Briguglio, C; Barsanti, S; Antonelli Incalzi, R; STORICO study group.

In: European Journal of Internal Medicine, Vol. 43, 09.2017, p. 62-68.

Research output: Contribution to journalArticle

Canonica, GW, Blasi, F, Scichilone, N, Simoni, L, Zullo, A, Giovannetti, C, Briguglio, C, Barsanti, S, Antonelli Incalzi, R & STORICO study group 2017, 'Characterization of circadian COPD symptoms by phenotype: Methodology of the STORICO observational study', European Journal of Internal Medicine, vol. 43, pp. 62-68. https://doi.org/10.1016/j.ejim.2017.05.021
Canonica, G W ; Blasi, F ; Scichilone, N ; Simoni, L ; Zullo, A ; Giovannetti, C ; Briguglio, C ; Barsanti, S ; Antonelli Incalzi, R ; STORICO study group. / Characterization of circadian COPD symptoms by phenotype: Methodology of the STORICO observational study. In: European Journal of Internal Medicine. 2017 ; Vol. 43. pp. 62-68.
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