Characterization of comorbid conditions burdening hidradenitis suppurativa

a multicentric observational study

Andrea Chiricozzi, Giulia Giovanardi, Dante R Caposiena Caro, Michela Iannone, Clara De Simone, Maria Vittoria Cannizzaro, Teresa Oranges, Barbara Fossati, Eleonora Di Matteo, Valentina Dini, Luca Bianchi, Ketty Peris

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, disabling, inflammatory skin disorder that primarily affects the hair follicle localized at the apocrine-gland-bearing areas of the body, including axillary, inguinal, buttocks, and anogenital areas, and it may be associated with a wide array of comorbid conditions. This study aimed to described comorbid conditions affecting HS patients and to detect any correlation with disease severity.

METHODS: Analyzing clinic database, we included all charts of patients visited at the HS outpatient clinic of three University Dermatologic Departments in order to describe demographic data, anthropometric measures, disease features, personal habits, clinical history, and presence of comorbidities.

RESULTS: Two hundred thirty-four patients, mostly females (62%), were enrolled in this study. Based on Hurley staging classification 41% of patients were classified as Hurley Stage I, 43.0% as Hurley II, and 16% Hurley III, with a mean mSartorius score value of 24.7 (SD: ±19.39) and a mean AISI score value of 12.5 (SD: ±11.93). The most frequently observed comorbidities were: obesity (26.1%), polycystic ovary syndrome (PCOS) (13.8% of the overall study population and 22.3% of females), hypertension (11.9%), dyslipidemia (9.9%), type II diabetes (9.5%), thyroid disorders (9.1%), nervous system disorders (7.1%), acne (6.7%), metabolic syndrome (4.4%), and Crohn's disease (3.6%). Obesity represented a key-comorbid condition increasing the likelihood of having more severe HS and PCOS (odds ratio 3.35 and 3.74, respectively).

CONCLUSIONS: HS is associated with a variety of comorbid conditions that should be considered to perform targeted routine screening and to improve HS management.

Original languageEnglish
JournalGiornale Italiano di Dermatologia e Venereologia
DOIs
Publication statusE-pub ahead of print - Oct 3 2018

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Hidradenitis Suppurativa
Observational Studies
Polycystic Ovary Syndrome
Comorbidity
Obesity
Apocrine Glands
Buttocks
Hair Follicle
Groin
Acne Vulgaris
Dyslipidemias
Ambulatory Care Facilities
Nervous System Diseases
Crohn Disease
Type 2 Diabetes Mellitus
Habits
Thyroid Gland
Odds Ratio
Demography
Databases

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Characterization of comorbid conditions burdening hidradenitis suppurativa : a multicentric observational study. / Chiricozzi, Andrea; Giovanardi, Giulia; Caposiena Caro, Dante R; Iannone, Michela; De Simone, Clara; Cannizzaro, Maria Vittoria; Oranges, Teresa; Fossati, Barbara; Di Matteo, Eleonora; Dini, Valentina; Bianchi, Luca; Peris, Ketty.

In: Giornale Italiano di Dermatologia e Venereologia, 03.10.2018.

Research output: Contribution to journalArticle

Chiricozzi, Andrea ; Giovanardi, Giulia ; Caposiena Caro, Dante R ; Iannone, Michela ; De Simone, Clara ; Cannizzaro, Maria Vittoria ; Oranges, Teresa ; Fossati, Barbara ; Di Matteo, Eleonora ; Dini, Valentina ; Bianchi, Luca ; Peris, Ketty. / Characterization of comorbid conditions burdening hidradenitis suppurativa : a multicentric observational study. In: Giornale Italiano di Dermatologia e Venereologia. 2018.
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abstract = "BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, disabling, inflammatory skin disorder that primarily affects the hair follicle localized at the apocrine-gland-bearing areas of the body, including axillary, inguinal, buttocks, and anogenital areas, and it may be associated with a wide array of comorbid conditions. This study aimed to described comorbid conditions affecting HS patients and to detect any correlation with disease severity.METHODS: Analyzing clinic database, we included all charts of patients visited at the HS outpatient clinic of three University Dermatologic Departments in order to describe demographic data, anthropometric measures, disease features, personal habits, clinical history, and presence of comorbidities.RESULTS: Two hundred thirty-four patients, mostly females (62{\%}), were enrolled in this study. Based on Hurley staging classification 41{\%} of patients were classified as Hurley Stage I, 43.0{\%} as Hurley II, and 16{\%} Hurley III, with a mean mSartorius score value of 24.7 (SD: ±19.39) and a mean AISI score value of 12.5 (SD: ±11.93). The most frequently observed comorbidities were: obesity (26.1{\%}), polycystic ovary syndrome (PCOS) (13.8{\%} of the overall study population and 22.3{\%} of females), hypertension (11.9{\%}), dyslipidemia (9.9{\%}), type II diabetes (9.5{\%}), thyroid disorders (9.1{\%}), nervous system disorders (7.1{\%}), acne (6.7{\%}), metabolic syndrome (4.4{\%}), and Crohn's disease (3.6{\%}). Obesity represented a key-comorbid condition increasing the likelihood of having more severe HS and PCOS (odds ratio 3.35 and 3.74, respectively).CONCLUSIONS: HS is associated with a variety of comorbid conditions that should be considered to perform targeted routine screening and to improve HS management.",
author = "Andrea Chiricozzi and Giulia Giovanardi and {Caposiena Caro}, {Dante R} and Michela Iannone and {De Simone}, Clara and Cannizzaro, {Maria Vittoria} and Teresa Oranges and Barbara Fossati and {Di Matteo}, Eleonora and Valentina Dini and Luca Bianchi and Ketty Peris",
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TY - JOUR

T1 - Characterization of comorbid conditions burdening hidradenitis suppurativa

T2 - a multicentric observational study

AU - Chiricozzi, Andrea

AU - Giovanardi, Giulia

AU - Caposiena Caro, Dante R

AU - Iannone, Michela

AU - De Simone, Clara

AU - Cannizzaro, Maria Vittoria

AU - Oranges, Teresa

AU - Fossati, Barbara

AU - Di Matteo, Eleonora

AU - Dini, Valentina

AU - Bianchi, Luca

AU - Peris, Ketty

PY - 2018/10/3

Y1 - 2018/10/3

N2 - BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, disabling, inflammatory skin disorder that primarily affects the hair follicle localized at the apocrine-gland-bearing areas of the body, including axillary, inguinal, buttocks, and anogenital areas, and it may be associated with a wide array of comorbid conditions. This study aimed to described comorbid conditions affecting HS patients and to detect any correlation with disease severity.METHODS: Analyzing clinic database, we included all charts of patients visited at the HS outpatient clinic of three University Dermatologic Departments in order to describe demographic data, anthropometric measures, disease features, personal habits, clinical history, and presence of comorbidities.RESULTS: Two hundred thirty-four patients, mostly females (62%), were enrolled in this study. Based on Hurley staging classification 41% of patients were classified as Hurley Stage I, 43.0% as Hurley II, and 16% Hurley III, with a mean mSartorius score value of 24.7 (SD: ±19.39) and a mean AISI score value of 12.5 (SD: ±11.93). The most frequently observed comorbidities were: obesity (26.1%), polycystic ovary syndrome (PCOS) (13.8% of the overall study population and 22.3% of females), hypertension (11.9%), dyslipidemia (9.9%), type II diabetes (9.5%), thyroid disorders (9.1%), nervous system disorders (7.1%), acne (6.7%), metabolic syndrome (4.4%), and Crohn's disease (3.6%). Obesity represented a key-comorbid condition increasing the likelihood of having more severe HS and PCOS (odds ratio 3.35 and 3.74, respectively).CONCLUSIONS: HS is associated with a variety of comorbid conditions that should be considered to perform targeted routine screening and to improve HS management.

AB - BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, disabling, inflammatory skin disorder that primarily affects the hair follicle localized at the apocrine-gland-bearing areas of the body, including axillary, inguinal, buttocks, and anogenital areas, and it may be associated with a wide array of comorbid conditions. This study aimed to described comorbid conditions affecting HS patients and to detect any correlation with disease severity.METHODS: Analyzing clinic database, we included all charts of patients visited at the HS outpatient clinic of three University Dermatologic Departments in order to describe demographic data, anthropometric measures, disease features, personal habits, clinical history, and presence of comorbidities.RESULTS: Two hundred thirty-four patients, mostly females (62%), were enrolled in this study. Based on Hurley staging classification 41% of patients were classified as Hurley Stage I, 43.0% as Hurley II, and 16% Hurley III, with a mean mSartorius score value of 24.7 (SD: ±19.39) and a mean AISI score value of 12.5 (SD: ±11.93). The most frequently observed comorbidities were: obesity (26.1%), polycystic ovary syndrome (PCOS) (13.8% of the overall study population and 22.3% of females), hypertension (11.9%), dyslipidemia (9.9%), type II diabetes (9.5%), thyroid disorders (9.1%), nervous system disorders (7.1%), acne (6.7%), metabolic syndrome (4.4%), and Crohn's disease (3.6%). Obesity represented a key-comorbid condition increasing the likelihood of having more severe HS and PCOS (odds ratio 3.35 and 3.74, respectively).CONCLUSIONS: HS is associated with a variety of comorbid conditions that should be considered to perform targeted routine screening and to improve HS management.

U2 - 10.23736/S0392-0488.18.06165-5

DO - 10.23736/S0392-0488.18.06165-5

M3 - Article

JO - Giornale Italiano di Dermatologia e Venereologia

JF - Giornale Italiano di Dermatologia e Venereologia

SN - 0392-0488

ER -