Characterization of corynebacterium parvum-induced suppressor cells of mouse NK and ADCC activity

Angela Santoni, Giorgio Santoni, Mario Piccoli, Ronald B. Herberman, Luigi Frati

Research output: Contribution to journalArticlepeer-review

Abstract

Treatment of mice with Corynebacterium parvum (Cp) resulted in a substantial decrease in natural killer activity in the spleen at 10 days. The decrease in cytotoxicity was associated with the presence of splenic nonadherent (NA) suppressor cells, capable of inhibiting natural as well as antibody-dependent cellular cytotoxicity (ADCC). The nonadherent suppressor cells appeared to be null cells, lacking detectable expression of Thy 1, L3T4 (CD4), Lyt 2 (CDE), or asialo-GM1 and could be physically separated from cells with NK activity by centrifugation on Percoll discontinuos density gradients. Our results indicate that Cp can negatively modulate cytolytic functions of NK cells by inhibiting the effector phase of cytotoxicity.

Original languageEnglish
Pages (from-to)363-387
Number of pages25
JournalImmunopharmacology and Immunotoxicology
Volume12
Issue number3
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

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