Caratterizzazione delle lesioni focali epatiche con mezzo di contrasto ecografico e metodica di imaging continuo a basso indice meccanico: Paragone con la TC spirale con contrasto

Translated title of the contribution: Characterization of focal liver lesions with a new ultrasound contrast agent using continuous low acoustic power imaging: Comparison with contrast enhanced spiral CT

Matteo Passamonti, Alessandro Vercelli, Andrea Azzaretti, Giuseppe Rodolico, Fabrizio Calliada

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose. To evaluate the concordance of the enhancement patterns of a new ultrasound contrast agent (SonoVue) with those obtained with dual-phase contrast-enhanced spiral CT (CE-CT) in the characterization of focal liver lesions (FLLs). Materials and methods. Sixty-two patients with focal liver lesions discovered at ultrasound and also studied with CECT underwent contrast-enhanced ultrasound using continuous low acoustic power imaging after receiving a 2.4 ml bolus of the new US contrast agent SonoVue®, consisting of a dispersion of sulphur hexafluoride microbubbles. The examinations were made using ATL HDI-5000, Acuson SEQUOIA and Aloka 5500 Prosound ultrasound systems with 5.2 MHz curved-array probes. The concordance between US and CE-CT images was evaluated on site by two radiologists blinded to CT results. The FLLs were assessed in the arterial (20 s after CM injection), portal (after 45-60 s) and late (after 120 s) phases for: 1) presence/absence of enhancement 2) distribution of enhancement (homogenous or target distribution, centripetal or centrifugal flow, and other), 3) qualitative enhancement pattern (hyperechoic, hypoechoic, or isoechoic) versus normal liver parenchyma. Results. The concordance between SonoVue-enhanced US and CE-CT was 85%. Moreover during portal venous phase with CEUS it was possible to differentiate between malignancy or benignity of 91% of lesions. Conclusions. The preliminary data obtained in this study suggest that continuous low acoustic power imaging and contrast-enhanced US show similar results to CT in contrast distribution and contrast enhancement patterns.

Translated title of the contributionCharacterization of focal liver lesions with a new ultrasound contrast agent using continuous low acoustic power imaging: Comparison with contrast enhanced spiral CT
Original languageItalian
Pages (from-to)358-369
Number of pages12
JournalRadiologia Medica
Volume109
Issue number4
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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