Characterization of FOX-3, an AmpC-type plasmid-mediated β-lactamase from an italian isolate of Klebsiella oxytoca

Anna Marchese, Guillaume Arlet, Gian Carlo Schito, Philippe H. Lagrange, Alain Philippon

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Klebsiella oxytoca 1731, which showed a wide spectrum of resistance to β-lactams, including cefoxitin, was isolated in 1994 from a patient in Genoa, Italy. This strain contained a plasmid-mediated AmpC β-lactamase with a pI of 7.25. Sequencing of the corresponding DNA of K. oxytoca 1731 revealed 96 and 97% identities of the deduced amino acid sequence with FOX-1 and FOX- 2, respectively.

Original languageEnglish
Pages (from-to)464-467
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume42
Issue number2
Publication statusPublished - Feb 1998

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Klebsiella oxytoca
Plasmids
Cefoxitin
Lactams
DNA Sequence Analysis
Italy
Amino Acid Sequence

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Characterization of FOX-3, an AmpC-type plasmid-mediated β-lactamase from an italian isolate of Klebsiella oxytoca. / Marchese, Anna; Arlet, Guillaume; Schito, Gian Carlo; Lagrange, Philippe H.; Philippon, Alain.

In: Antimicrobial Agents and Chemotherapy, Vol. 42, No. 2, 02.1998, p. 464-467.

Research output: Contribution to journalArticle

Marchese, A, Arlet, G, Schito, GC, Lagrange, PH & Philippon, A 1998, 'Characterization of FOX-3, an AmpC-type plasmid-mediated β-lactamase from an italian isolate of Klebsiella oxytoca', Antimicrobial Agents and Chemotherapy, vol. 42, no. 2, pp. 464-467.
Marchese, Anna ; Arlet, Guillaume ; Schito, Gian Carlo ; Lagrange, Philippe H. ; Philippon, Alain. / Characterization of FOX-3, an AmpC-type plasmid-mediated β-lactamase from an italian isolate of Klebsiella oxytoca. In: Antimicrobial Agents and Chemotherapy. 1998 ; Vol. 42, No. 2. pp. 464-467.
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