Characterization of gut microbiota in patients with metabolic syndrome candidates for bariatric/metabolic surgery: Preliminary findings of a multi-center prospective study

Flavio De Maio, Cristian Eugeniu Boru, Marcello Avallone, Nunzio Velotti, Delia Mercedes Bianco, Danila Capoccia, Francesco Greco, Gloria Guarisco, Manuela Nogara, Maurizio Sanguinetti, Ornella Verrastro, Brunella Capaldo, Mario Musella, Marco Raffaelli, Giovanni Delogu, Gianfranco Silecchia, Frida Leonetti

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: gut microbiota (GM) seems to be involved in the pathophysiology and progression of both metabolic syndrome (MS) and obesity. The aim was to investigate GM's composition in patients with severe obesity, candidates for bariatric/metabolic surgery BMS. Materials and Methods: Multicentre, prospective, cohort study, enrolling 84 patients with BMI 40–55 kg/m2, divided by metabolic status (MS) in healthy (group A), pre-MS (B), or MS (C). Results: No differences were found regarding anthropometric, nutritional parameters, except for vitamin D. As a whole the alpha and beta diversity examinations showed no statistical differences in GM profile. A total of 5/7 phyla with relative frequencies were identified above 0.1% (Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria, Verrucomicrobia). Fusobacteria and Patescibacteria represented the less abundant. There were no significant differences in the top ten genera. Data on Bacteroidetes (inversely related to triglycerides and LDL and directly related to HDL levels) and on Firmicutes (opposite trend) relative abundances suggest no differences among the three conditions. No correlation between the relative abundance of the main phyla and plasmatic glucose levels was observed. Conclusions: In a selected cohort of patients with obesity, MS did not affect the preoperative GM's profile. Severe obesity, per se, seems to be an independent condition affecting GM.

Original languageEnglish
Article number109079
JournalDiabetes Research and Clinical Practice
Volume180
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Bariatric/metabolic surgery
  • Gastric bypass
  • Gut microbiota
  • Metabolic syndrome
  • Obesity

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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