Characterization of IgD. II. Molecular forms of IgD in human B cells

G. Corte, G. Viale, E. Cosulich, A. Bargellesi, M. Ferrarini

Research output: Contribution to journalArticlepeer-review

Abstract

Endogenous and surface labelling techniques were used on human lymphoid cells to characterize intracytoplasmic, membrane and secreted IgD. IgD synthesized by lymphocytes and inserted into the cell membrane displayed a single molecular form with the same mobility in sodium dodecyl sulphase polyacrylamide gel electrophoresis (SDS-PAGE) as the previously described slow migrating serum IgD1. Plasma cells produced and secreted IgD1 and another IgD corresponding to the faster-moving serum IgD2. Conversion of one molecular form into the other was never observed, thus indicating that neither molecule is a precursor or a degradation product of the other.

Original languageEnglish
Pages (from-to)275-280
Number of pages6
JournalScandinavian Journal of Immunology
Volume10
Issue number3
DOIs
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Immunology

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