Characterization of Left Ventricular Activation in Patients with Heart Failure and Left Bundle-Branch Block

Angelo Auricchio, Cecilia Fantoni, Francois Regoli, Corrado Carbucicchio, Andreas Goette, Christoph Geller, Michael Kloss, Helmut Klein

Research output: Contribution to journalArticle

Abstract

Background-Conventional activation mapping in the dilated human left ventricle (LV) with left bundle-branch block (LBBB) morphology is incomplete given the limited number of recording sites that may be collected in a reasonable time and given the lack of precision in marking specific anatomic locations. Methods and Results-We studied LV activation sequences in 24 patients with heart failure and LBBB QRS morphology with simultaneous application of 3D contact and noncontact mapping during intrinsic rhythm and asynchronous pacing. Approximately one third of the patients with typical LBBB QRS morphology had normal transseptal activation time and a slightly prolonged or near-normal LV endocardial activation time. A "U-shaped" activation wave front was present in 23 patients because of a line of block that was located anteriorly (n = 12), laterally (n = 8), and inferiorly (n = 3). Patients with a lateral line of block had significantly shorter QRS (P

Original languageEnglish
Pages (from-to)1133-1139
Number of pages7
JournalCirculation
Volume109
Issue number9
DOIs
Publication statusPublished - Mar 9 2004

Keywords

  • Bundle-branch block
  • Heart failure
  • Mapping

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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