Characterization of liver nodules in patients with chronic liver disease by MRI: performance of the Liver Imaging Reporting and Data System (LI-RADS v.2018) scale and its comparison with the Likert scale

Andrea Esposito, Valentina Buscarino, Dario Raciti, Elena Casiraghi, Matteo Manini, Pietro Biondetti, Laura Forzenigo

Research output: Contribution to journalArticle

Abstract

Objectives: To evaluate the performance of the LI-RADS v.2018 scale by comparing it with the Likert scale, in the characterization of liver lesions. Methods: A total of 39 patients with chronic liver disease underwent MR examination for characterization of 44 liver lesions. Images were independently analyzed by two radiologists using the LI-RADS scale and by another two radiologists using the Likert scale. The reference standard used was either histopathological evaluation or a 4-year MRI follow-up. Receiver operating characteristic analysis was performed. Results: The LI-RADS scale obtained an accuracy of 80%, a sensitivity of 72%, a specificity of 93%, a positive predictive value (PPV) of 93% and a negative predictive value (NPV) of 70%, while the Likert scale achieved an accuracy of 79%, a sensitivity of 73%, a specificity of 87%, a PPV of 89% and a NPV of 70%. The area under the curve (AUC) was 85% for the LI-RADS scale and 83% for the Likert scale. The inter-observer agreement was strong (k = 0.89) between the LI-RADS evaluators and moderate (k = 0.69) between the Likert evaluators. Conclusions: There was no statistically significant difference between the performances of the two scales; nevertheless, we suggest that the LI-RADS scale be used, as it appeared more objective and consistent.

Original languageEnglish
JournalRadiologia Medica
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Information Systems
Liver Diseases
Chronic Disease
Liver
ROC Curve
Area Under Curve
Radiologists

Keywords

  • Carcinoma, hepatocellular
  • Data interpretation, statistical
  • Early detection of cancer
  • Liver cirrhosis
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{b443707e4660425fbaee2e76c60d01dc,
title = "Characterization of liver nodules in patients with chronic liver disease by MRI: performance of the Liver Imaging Reporting and Data System (LI-RADS v.2018) scale and its comparison with the Likert scale",
abstract = "Objectives: To evaluate the performance of the LI-RADS v.2018 scale by comparing it with the Likert scale, in the characterization of liver lesions. Methods: A total of 39 patients with chronic liver disease underwent MR examination for characterization of 44 liver lesions. Images were independently analyzed by two radiologists using the LI-RADS scale and by another two radiologists using the Likert scale. The reference standard used was either histopathological evaluation or a 4-year MRI follow-up. Receiver operating characteristic analysis was performed. Results: The LI-RADS scale obtained an accuracy of 80{\%}, a sensitivity of 72{\%}, a specificity of 93{\%}, a positive predictive value (PPV) of 93{\%} and a negative predictive value (NPV) of 70{\%}, while the Likert scale achieved an accuracy of 79{\%}, a sensitivity of 73{\%}, a specificity of 87{\%}, a PPV of 89{\%} and a NPV of 70{\%}. The area under the curve (AUC) was 85{\%} for the LI-RADS scale and 83{\%} for the Likert scale. The inter-observer agreement was strong (k = 0.89) between the LI-RADS evaluators and moderate (k = 0.69) between the Likert evaluators. Conclusions: There was no statistically significant difference between the performances of the two scales; nevertheless, we suggest that the LI-RADS scale be used, as it appeared more objective and consistent.",
keywords = "Carcinoma, hepatocellular, Data interpretation, statistical, Early detection of cancer, Liver cirrhosis, Magnetic resonance imaging",
author = "Andrea Esposito and Valentina Buscarino and Dario Raciti and Elena Casiraghi and Matteo Manini and Pietro Biondetti and Laura Forzenigo",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s11547-019-01092-y",
language = "English",
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TY - JOUR

T1 - Characterization of liver nodules in patients with chronic liver disease by MRI

T2 - performance of the Liver Imaging Reporting and Data System (LI-RADS v.2018) scale and its comparison with the Likert scale

AU - Esposito, Andrea

AU - Buscarino, Valentina

AU - Raciti, Dario

AU - Casiraghi, Elena

AU - Manini, Matteo

AU - Biondetti, Pietro

AU - Forzenigo, Laura

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives: To evaluate the performance of the LI-RADS v.2018 scale by comparing it with the Likert scale, in the characterization of liver lesions. Methods: A total of 39 patients with chronic liver disease underwent MR examination for characterization of 44 liver lesions. Images were independently analyzed by two radiologists using the LI-RADS scale and by another two radiologists using the Likert scale. The reference standard used was either histopathological evaluation or a 4-year MRI follow-up. Receiver operating characteristic analysis was performed. Results: The LI-RADS scale obtained an accuracy of 80%, a sensitivity of 72%, a specificity of 93%, a positive predictive value (PPV) of 93% and a negative predictive value (NPV) of 70%, while the Likert scale achieved an accuracy of 79%, a sensitivity of 73%, a specificity of 87%, a PPV of 89% and a NPV of 70%. The area under the curve (AUC) was 85% for the LI-RADS scale and 83% for the Likert scale. The inter-observer agreement was strong (k = 0.89) between the LI-RADS evaluators and moderate (k = 0.69) between the Likert evaluators. Conclusions: There was no statistically significant difference between the performances of the two scales; nevertheless, we suggest that the LI-RADS scale be used, as it appeared more objective and consistent.

AB - Objectives: To evaluate the performance of the LI-RADS v.2018 scale by comparing it with the Likert scale, in the characterization of liver lesions. Methods: A total of 39 patients with chronic liver disease underwent MR examination for characterization of 44 liver lesions. Images were independently analyzed by two radiologists using the LI-RADS scale and by another two radiologists using the Likert scale. The reference standard used was either histopathological evaluation or a 4-year MRI follow-up. Receiver operating characteristic analysis was performed. Results: The LI-RADS scale obtained an accuracy of 80%, a sensitivity of 72%, a specificity of 93%, a positive predictive value (PPV) of 93% and a negative predictive value (NPV) of 70%, while the Likert scale achieved an accuracy of 79%, a sensitivity of 73%, a specificity of 87%, a PPV of 89% and a NPV of 70%. The area under the curve (AUC) was 85% for the LI-RADS scale and 83% for the Likert scale. The inter-observer agreement was strong (k = 0.89) between the LI-RADS evaluators and moderate (k = 0.69) between the Likert evaluators. Conclusions: There was no statistically significant difference between the performances of the two scales; nevertheless, we suggest that the LI-RADS scale be used, as it appeared more objective and consistent.

KW - Carcinoma, hepatocellular

KW - Data interpretation, statistical

KW - Early detection of cancer

KW - Liver cirrhosis

KW - Magnetic resonance imaging

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