TY - JOUR
T1 - Characterization of liver nodules in patients with chronic liver disease by MRI
T2 - performance of the Liver Imaging Reporting and Data System (LI-RADS v.2018) scale and its comparison with the Likert scale
AU - Esposito, Andrea
AU - Buscarino, Valentina
AU - Raciti, Dario
AU - Casiraghi, Elena
AU - Manini, Matteo
AU - Biondetti, Pietro
AU - Forzenigo, Laura
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Objectives: To evaluate the performance of the LI-RADS v.2018 scale by comparing it with the Likert scale, in the characterization of liver lesions. Methods: A total of 39 patients with chronic liver disease underwent MR examination for characterization of 44 liver lesions. Images were independently analyzed by two radiologists using the LI-RADS scale and by another two radiologists using the Likert scale. The reference standard used was either histopathological evaluation or a 4-year MRI follow-up. Receiver operating characteristic analysis was performed. Results: The LI-RADS scale obtained an accuracy of 80%, a sensitivity of 72%, a specificity of 93%, a positive predictive value (PPV) of 93% and a negative predictive value (NPV) of 70%, while the Likert scale achieved an accuracy of 79%, a sensitivity of 73%, a specificity of 87%, a PPV of 89% and a NPV of 70%. The area under the curve (AUC) was 85% for the LI-RADS scale and 83% for the Likert scale. The inter-observer agreement was strong (k = 0.89) between the LI-RADS evaluators and moderate (k = 0.69) between the Likert evaluators. Conclusions: There was no statistically significant difference between the performances of the two scales; nevertheless, we suggest that the LI-RADS scale be used, as it appeared more objective and consistent.
AB - Objectives: To evaluate the performance of the LI-RADS v.2018 scale by comparing it with the Likert scale, in the characterization of liver lesions. Methods: A total of 39 patients with chronic liver disease underwent MR examination for characterization of 44 liver lesions. Images were independently analyzed by two radiologists using the LI-RADS scale and by another two radiologists using the Likert scale. The reference standard used was either histopathological evaluation or a 4-year MRI follow-up. Receiver operating characteristic analysis was performed. Results: The LI-RADS scale obtained an accuracy of 80%, a sensitivity of 72%, a specificity of 93%, a positive predictive value (PPV) of 93% and a negative predictive value (NPV) of 70%, while the Likert scale achieved an accuracy of 79%, a sensitivity of 73%, a specificity of 87%, a PPV of 89% and a NPV of 70%. The area under the curve (AUC) was 85% for the LI-RADS scale and 83% for the Likert scale. The inter-observer agreement was strong (k = 0.89) between the LI-RADS evaluators and moderate (k = 0.69) between the Likert evaluators. Conclusions: There was no statistically significant difference between the performances of the two scales; nevertheless, we suggest that the LI-RADS scale be used, as it appeared more objective and consistent.
KW - Carcinoma, hepatocellular
KW - Data interpretation, statistical
KW - Early detection of cancer
KW - Liver cirrhosis
KW - Magnetic resonance imaging
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U2 - 10.1007/s11547-019-01092-y
DO - 10.1007/s11547-019-01092-y
M3 - Article
AN - SCOPUS:85073959119
VL - 125
SP - 15
EP - 23
JO - Radiologia Medica
JF - Radiologia Medica
SN - 0033-8362
IS - 1
ER -