Characterization of metalloproteinases, oxidative status and inflammation levels in the different stages of fibrosis in HCV patients

F. Capone, E. Guerriero, A. Sorice, P. Maio, G. Colonna, G. Castello, S. Costantini

Research output: Contribution to journalArticle

Abstract

Objectives: This study was aimed at searching noninvasive markers of the transition from mild to severe fibrosis stage in HCV patients undergoing hepatic fibrosis. Design and methods: Thirty-three patients affected by chronic HCV vs. twenty healthy donors were evaluated for the serum levels of several circulating matrix metalloproteinases (MMPs), TRAIL and β-NGF by multiplex biometric ELISA based immunoassay and anti- and pro-oxidant status (d-ROMs, BAP and NO) using a Diacron automated method. Results: HCV patients displayed increased expression levels of MMP-8, MMP-9, TRAIL and β-NGF, and an imbalance between pro- and antioxidant status, that contribute to liver fibrosis. Conclusions: Since the determination of these parameters represents a reliable and easily applicable method, these parameters are suggested as serum surrogate markers for HCV patients in the routine clinical practice.

Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalClinical Biochemistry
Volume45
Issue number7-8
DOIs
Publication statusPublished - May 2012

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Keywords

  • Cytokines
  • Fibrosis
  • HCV
  • Marker
  • MMPs
  • Oxidative stress

ASJC Scopus subject areas

  • Clinical Biochemistry

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