Characterization of Microelectrode Recordings for the Subthalamic Nucleus identification in Parkinson's disease

S. Coelli, V. Levi, J. Del Vecchio Del Vecchio, E. Mailland, S. Rinaldo, R. Eleopra, A. M. Bianchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for Parkinson's disease, when the pharmacological approach has no more effect. DBS efficacy strongly depends on the accurate localization of the STN and the adequate positioning of the stimulation electrode during DBS stereotactic surgery. During this procedure, the analysis of microelectrode recordings (MER) is fundamental to assess the correct localization. Therefore, in this work, we explore different signal feature types for the characterization of the MER signals associated to STN from NON-STN structures. We extracted a set of spike-dependent (action potential domain) and spike-independent features in the time and frequency domain to evaluate their usefulness in distinguishing the STN from other structures. We discuss the results from a physiological and methodological point of view, showing the superiority of features having a direct electrophysiological interpretation.Clinical Relevance - The identification of a simple, clinically interpretable, and powerful set of features for the STN localization would support the clinical positioning of the DBS electrode, improving the treatment outcome.

Original languageEnglish
Title of host publication42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEnabling Innovative Technologies for Global Healthcare, EMBC 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3485-3488
Number of pages4
ISBN (Electronic)9781728119908
DOIs
Publication statusPublished - Jul 2020
Event42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020 - Montreal, Canada
Duration: Jul 20 2020Jul 24 2020

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume2020-July
ISSN (Print)1557-170X

Conference

Conference42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020
CountryCanada
CityMontreal
Period7/20/207/24/20

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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