Characterization of pABVA01, a plasmid encoding the OXA-24 carbapenemase from Italian isolates of Acinetobacter baumannii

Marco Maria D'Andrea, Tommaso Giani, Silvia D'Arezzo, Alessandro Capone, Nicola Petrosillo, Paolo Visca, Francesco Luzzaro, Gian Maria Rossolini

Research output: Contribution to journalArticlepeer-review

Abstract

Two epidemiologically unrelated carbapenem-resistant Acinetobacter baumannii isolates were investigated as representatives of the first Italian isolates producing the OXA-24 carbapenemase. Both isolates were of European clonal lineage II and carried an identical OXA-24-encoding plasmid, named pABVA01. Comparative analysis revealed that in pABVA01, blaOXA-24 was part of a DNA module flanked by conserved inverted repeats homologous to XerC/XerD binding sites, which in other Acinetobacter plasmids flank different DNA modules, suggesting mobilization by a novel site-specific recombination mechanism.

Original languageEnglish
Pages (from-to)3528-3533
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume53
Issue number8
DOIs
Publication statusPublished - Aug 2009

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Pharmacology

Fingerprint

Dive into the research topics of 'Characterization of pABVA01, a plasmid encoding the OXA-24 carbapenemase from Italian isolates of Acinetobacter baumannii'. Together they form a unique fingerprint.

Cite this