Characterization of silver sulfadiazine-loaded solid lipid nanoparticles by thermal analysis

Catenacci Laura, Sorrenti Milena, Bruni Giovanna, Bonferoni Maria Cristina, Sandri Giuseppina, Bettinetti Giampiero

Research output: Contribution to journalArticle

Abstract

The aim of this study is the solid-state characterization of solid lipid nanoparticles (SLN) based on Compritol® 888 (C888) and Lutrol® F68 (F68), loaded with silver sulfadiazine (AgSD), used to develop sponge-like dressings to treat chronic skin ulcers such as decubitis and leg ulcers. Silver compounds like AgSD, in fact, are used to prevent and/or to treat wound colonization that could impair healing, also in the case of antibiotic-resistant bacteria. Thermal analysis, with support from powder X-ray diffractometry and Fourier transform infrared spectroscopy, is used to characterize lipid and drug bulk, unloaded and drug-loaded SLN. In particular, differential scanning calorimetry is used to investigate the degree of crystallinity and the solid-state modification of lipid, two parameters correlated to drug incorporation and drug release rates. The solid-state characterization demonstrates AgSD entrapment in C888 as a core enclosed into F68 shell. AgSD SLN are also stored at different temperatures 25 and 37 C, respectively, to study the effect of storage conditions, that induce an increase of the lipid crystallinity index correlated to drug release from the lipid matrix.

Original languageEnglish
Pages (from-to)2149-2155
Number of pages7
JournalJournal of Thermal Analysis and Calorimetry
Volume111
Issue number3
DOIs
Publication statusPublished - Mar 2013

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Keywords

  • Differential scanning calorimetry
  • Fourier transform infrared spectroscopy
  • Silver sulfadiazine
  • Solid lipid nanoparticles
  • X-ray powder diffractometry

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Condensed Matter Physics

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