Characterization of T lymphocytes in severe COVID-19 patients

Daniela Fenoglio, Chiara Dentone, Alessia Parodi, Antonio Di Biagio, Federica Bozzano, Antonio Vena, Marina Fabbi, Francesca Ferrera, Tiziana Altosole, Bianca Bruzzone, Mauro Giacomini, Paolo Pelosi, Andrea De Maria, Matteo Bassetti, Raffaele De Palma, Gilberto Filaci

Research output: Contribution to journalArticlepeer-review


In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.

Original languageEnglish
JournalJournal of Medical Virology
Publication statusAccepted/In press - 2021


  • adaptive immunity
  • COVID-19
  • SARS-CoV-2
  • T lymphocytes

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


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