Characterization of the family of dimers associated with Fc receptors (Fc∈RI and FcγRIII)

Odile Letourneur, Ian C S Kennedy, Anna T. Brini, John R. Ortaldo, John J. O'Shea, Jean Pierre Kinet

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Abstract

The receptor for IgE (Fc∈RI) is a multimeric complex containing one α chain, one β chain with four transmembrane domains and one homodimer of disulfide-linked γ-chains. The Fc∈RI γ-chains form additional disulfide-linked dimers with the homologous ζ- and η-chains, as part of the TCR complex. The low affinity receptor for IgG (FcγRIII)2 on NK cells is also associated with ζ-chains. Here we show that the γ-chain is expressed in NK cells both as a group of heterogenous γγ homodimers and also as a heterodimer bound to ζ. FcγRIIIA is associated with three types of dimers ζζ, γζ, and notably γγ as well. In fact, γγ appears to be the predominant species associating with FCγRIIIA. The surface expressed Fc∈RI also associates with the same group of heterogenous γγ homodimers. We also show that there is no C-terminal posttranslational cleavage of γ occurring before its insertion into the plasma membrane as previously suggested. Thus, like the TCR, FcγRIIIA may form a variety of receptor isoforms, though at present we do not understand the functional implications of these structures.

Original languageEnglish
Pages (from-to)2652-2656
Number of pages5
JournalJournal of Immunology
Volume147
Issue number8
Publication statusPublished - Oct 15 1991

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Fc Receptors
Natural Killer Cells
Disulfides
IgG Receptors
IgE Receptors
Protein Isoforms
Cell Membrane

ASJC Scopus subject areas

  • Immunology

Cite this

Letourneur, O., Kennedy, I. C. S., Brini, A. T., Ortaldo, J. R., O'Shea, J. J., & Kinet, J. P. (1991). Characterization of the family of dimers associated with Fc receptors (Fc∈RI and FcγRIII). Journal of Immunology, 147(8), 2652-2656.

Characterization of the family of dimers associated with Fc receptors (Fc∈RI and FcγRIII). / Letourneur, Odile; Kennedy, Ian C S; Brini, Anna T.; Ortaldo, John R.; O'Shea, John J.; Kinet, Jean Pierre.

In: Journal of Immunology, Vol. 147, No. 8, 15.10.1991, p. 2652-2656.

Research output: Contribution to journalArticle

Letourneur, O, Kennedy, ICS, Brini, AT, Ortaldo, JR, O'Shea, JJ & Kinet, JP 1991, 'Characterization of the family of dimers associated with Fc receptors (Fc∈RI and FcγRIII)', Journal of Immunology, vol. 147, no. 8, pp. 2652-2656.
Letourneur O, Kennedy ICS, Brini AT, Ortaldo JR, O'Shea JJ, Kinet JP. Characterization of the family of dimers associated with Fc receptors (Fc∈RI and FcγRIII). Journal of Immunology. 1991 Oct 15;147(8):2652-2656.
Letourneur, Odile ; Kennedy, Ian C S ; Brini, Anna T. ; Ortaldo, John R. ; O'Shea, John J. ; Kinet, Jean Pierre. / Characterization of the family of dimers associated with Fc receptors (Fc∈RI and FcγRIII). In: Journal of Immunology. 1991 ; Vol. 147, No. 8. pp. 2652-2656.
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