TY - JOUR
T1 - Characterization of the human gene coding for the swelling-dependent chloride channel I(Cln) at position 11q13.5-14.1 (CLNSIA) and further characterization of the chromosome 6 (CLNS1B) localization
AU - Nagl, Ulrich O.
AU - Erdel, Martin
AU - Bergmann, Friederike
AU - Oehl, Bernhard
AU - Scandella, Elke
AU - Musante, Luciana
AU - Galietta, Luis J V
AU - Gschwentner, Martin
AU - Fürst, Johannes
AU - Schmarda, Andreas
AU - Hofer, Sabine
AU - Utermann, Gerd
AU - Deetjen, Peter
AU - Paulmichl, Markus
PY - 1998/3/16
Y1 - 1998/3/16
N2 - Expression cloning revealed a chloride channel (I(Cln)) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human I(Cln)-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A.
AB - Expression cloning revealed a chloride channel (I(Cln)) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human I(Cln)-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A.
KW - Human chromosomal localization
KW - I(Cln)
KW - RVD
KW - Swelling-dependent chloride channel
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U2 - 10.1016/S0378-1119(98)00002-X
DO - 10.1016/S0378-1119(98)00002-X
M3 - Article
C2 - 9524223
AN - SCOPUS:0032536889
VL - 209
SP - 59
EP - 63
JO - Gene
JF - Gene
SN - 0378-1119
IS - 1-2
ER -