Characterization of the human gene coding for the swelling-dependent chloride channel I(Cln) at position 11q13.5-14.1 (CLNSIA) and further characterization of the chromosome 6 (CLNS1B) localization

Ulrich O. Nagl; Martin Erdel; Friederike Bergmann; Bernhard Oehl; Elke Scandella; Luciana Musante; Luis J V Galietta; Martin Gschwentner; Johannes Fürst; Andreas Schmarda; Sabine Hofer; Gerd Utermann; Peter Deetjen; Markus Paulmichl

doi:10.1016/S0378-1119(98)00002-X

Characterization of the human gene coding for the swelling-dependent chloride channel I(Cln) at position 11q13.5-14.1 (CLNSIA) and further characterization of the chromosome 6 (CLNS1B) localization

Ulrich O. Nagl, Martin Erdel, Friederike Bergmann, Bernhard Oehl, Elke Scandella, Luciana Musante, Luis J V Galietta, Martin Gschwentner, Johannes Fürst, Andreas Schmarda, Sabine Hofer, Gerd Utermann, Peter Deetjen, Markus Paulmichl

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Expression cloning revealed a chloride channel (I(Cln)) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human I(Cln)-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A.

Original language	English
Pages (from-to)	59-63
Number of pages	5
Journal	Gene
Volume	209
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-1119(98)00002-X
Publication status	Published - Mar 16 1998

Keywords

Human chromosomal localization
I(Cln)
RVD
Swelling-dependent chloride channel

ASJC Scopus subject areas

Genetics

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10.1016/S0378-1119(98)00002-X

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Nagl, U. O., Erdel, M., Bergmann, F., Oehl, B., Scandella, E., Musante, L., Galietta, L. J. V., Gschwentner, M., Fürst, J., Schmarda, A., Hofer, S., Utermann, G., Deetjen, P., & Paulmichl, M. (1998). Characterization of the human gene coding for the swelling-dependent chloride channel I(Cln) at position 11q13.5-14.1 (CLNSIA) and further characterization of the chromosome 6 (CLNS1B) localization. Gene, 209(1-2), 59-63. https://doi.org/10.1016/S0378-1119(98)00002-X

Characterization of the human gene coding for the swelling-dependent chloride channel I(Cln) at position 11q13.5-14.1 (CLNSIA) and further characterization of the chromosome 6 (CLNS1B) localization. / Nagl, Ulrich O.; Erdel, Martin; Bergmann, Friederike; Oehl, Bernhard; Scandella, Elke; Musante, Luciana; Galietta, Luis J V; Gschwentner, Martin; Fürst, Johannes; Schmarda, Andreas; Hofer, Sabine; Utermann, Gerd; Deetjen, Peter; Paulmichl, Markus.

In: Gene, Vol. 209, No. 1-2, 16.03.1998, p. 59-63.

Research output: Contribution to journal › Article › peer-review

Nagl, UO, Erdel, M, Bergmann, F, Oehl, B, Scandella, E, Musante, L, Galietta, LJV, Gschwentner, M, Fürst, J, Schmarda, A, Hofer, S, Utermann, G, Deetjen, P & Paulmichl, M 1998, 'Characterization of the human gene coding for the swelling-dependent chloride channel I(Cln) at position 11q13.5-14.1 (CLNSIA) and further characterization of the chromosome 6 (CLNS1B) localization', Gene, vol. 209, no. 1-2, pp. 59-63. https://doi.org/10.1016/S0378-1119(98)00002-X

Nagl, Ulrich O. ; Erdel, Martin ; Bergmann, Friederike ; Oehl, Bernhard ; Scandella, Elke ; Musante, Luciana ; Galietta, Luis J V ; Gschwentner, Martin ; Fürst, Johannes ; Schmarda, Andreas ; Hofer, Sabine ; Utermann, Gerd ; Deetjen, Peter ; Paulmichl, Markus. / Characterization of the human gene coding for the swelling-dependent chloride channel I(Cln) at position 11q13.5-14.1 (CLNSIA) and further characterization of the chromosome 6 (CLNS1B) localization. In: Gene. 1998 ; Vol. 209, No. 1-2. pp. 59-63.

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abstract = "Expression cloning revealed a chloride channel (I(Cln)) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human I(Cln)-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A.",

keywords = "Human chromosomal localization, I(Cln), RVD, Swelling-dependent chloride channel",

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AU - Nagl, Ulrich O.

AU - Erdel, Martin

AU - Bergmann, Friederike

AU - Oehl, Bernhard

AU - Scandella, Elke

AU - Musante, Luciana

AU - Galietta, Luis J V

AU - Gschwentner, Martin

AU - Fürst, Johannes

AU - Schmarda, Andreas

AU - Hofer, Sabine

AU - Utermann, Gerd

AU - Deetjen, Peter

AU - Paulmichl, Markus

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N2 - Expression cloning revealed a chloride channel (I(Cln)) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human I(Cln)-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A.

AB - Expression cloning revealed a chloride channel (I(Cln)) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human I(Cln)-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A.

KW - Human chromosomal localization

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