Characterization of the human gene coding for the swelling-dependent chloride channel I(Cln) at position 11q13.5-14.1 (CLNSIA) and further characterization of the chromosome 6 (CLNS1B) localization

Ulrich O. Nagl, Martin Erdel, Friederike Bergmann, Bernhard Oehl, Elke Scandella, Luciana Musante, Luis J V Galietta, Martin Gschwentner, Johannes Fürst, Andreas Schmarda, Sabine Hofer, Gerd Utermann, Peter Deetjen, Markus Paulmichl

Research output: Contribution to journalArticlepeer-review

Abstract

Expression cloning revealed a chloride channel (I(Cln)) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human I(Cln)-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalGene
Volume209
Issue number1-2
DOIs
Publication statusPublished - Mar 16 1998

Keywords

  • Human chromosomal localization
  • I(Cln)
  • RVD
  • Swelling-dependent chloride channel

ASJC Scopus subject areas

  • Genetics

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