Caracterização do complexo de inclusão ropivacaína: β-ciclodextrina

Translated title of the contribution: Characterization of the inclusion complex ropivacaine: β-cyclodextrin

Leonardo Fernandes Fraceto, Marcos Moisés Gonçalves, Carolina Morales Moraes, Daniele Ribeiro De Araújo, Luciana Zanella, Eneida De Paula, Thelma De Aguiar Pertinhez

Research output: Contribution to journalArticle

Abstract

Ropivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with β-cyclodextrin (β-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:β-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:β-CD. DOSY-NMR shows that the association constant is 55.5 M-1. Longitudinal relaxation time results show that RVC changes its mobility in the presence of β-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment.

Original languagePortuguese
Pages (from-to)1203-1207
Number of pages5
JournalQuimica Nova
Volume30
Issue number5
Publication statusPublished - Sep 2007

Fingerprint

Cyclodextrins
Local Anesthetics
Nuclear magnetic resonance
Complexation
Stoichiometry
Relaxation time
ropivacaine
Association reactions

Keywords

  • Cyclodextrin
  • NMR
  • Ropivacaine

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Fraceto, L. F., Gonçalves, M. M., Moraes, C. M., De Araújo, D. R., Zanella, L., De Paula, E., & Pertinhez, T. D. A. (2007). Caracterização do complexo de inclusão ropivacaína: β-ciclodextrina. Quimica Nova, 30(5), 1203-1207.

Caracterização do complexo de inclusão ropivacaína : β-ciclodextrina. / Fraceto, Leonardo Fernandes; Gonçalves, Marcos Moisés; Moraes, Carolina Morales; De Araújo, Daniele Ribeiro; Zanella, Luciana; De Paula, Eneida; Pertinhez, Thelma De Aguiar.

In: Quimica Nova, Vol. 30, No. 5, 09.2007, p. 1203-1207.

Research output: Contribution to journalArticle

Fraceto, LF, Gonçalves, MM, Moraes, CM, De Araújo, DR, Zanella, L, De Paula, E & Pertinhez, TDA 2007, 'Caracterização do complexo de inclusão ropivacaína: β-ciclodextrina', Quimica Nova, vol. 30, no. 5, pp. 1203-1207.
Fraceto LF, Gonçalves MM, Moraes CM, De Araújo DR, Zanella L, De Paula E et al. Caracterização do complexo de inclusão ropivacaína: β-ciclodextrina. Quimica Nova. 2007 Sep;30(5):1203-1207.
Fraceto, Leonardo Fernandes ; Gonçalves, Marcos Moisés ; Moraes, Carolina Morales ; De Araújo, Daniele Ribeiro ; Zanella, Luciana ; De Paula, Eneida ; Pertinhez, Thelma De Aguiar. / Caracterização do complexo de inclusão ropivacaína : β-ciclodextrina. In: Quimica Nova. 2007 ; Vol. 30, No. 5. pp. 1203-1207.
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