Caracterização do complexo de inclusão ropivacaína: β-ciclodextrina

Translated title of the contribution: Characterization of the inclusion complex ropivacaine: β-cyclodextrin

Leonardo Fernandes Fraceto, Marcos Moisés Gonçalves, Carolina Morales Moraes, Daniele Ribeiro De Araújo, Luciana Zanella, Eneida De Paula, Thelma De Aguiar Pertinhez

Research output: Contribution to journalArticle


Ropivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with β-cyclodextrin (β-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:β-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:β-CD. DOSY-NMR shows that the association constant is 55.5 M-1. Longitudinal relaxation time results show that RVC changes its mobility in the presence of β-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment.

Translated title of the contributionCharacterization of the inclusion complex ropivacaine: β-cyclodextrin
Original languagePortuguese
Pages (from-to)1203-1207
Number of pages5
JournalQuimica Nova
Issue number5
Publication statusPublished - Sep 2007


  • Cyclodextrin
  • NMR
  • Ropivacaine

ASJC Scopus subject areas

  • Chemistry(all)

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    Fraceto, L. F., Gonçalves, M. M., Moraes, C. M., De Araújo, D. R., Zanella, L., De Paula, E., & Pertinhez, T. D. A. (2007). Caracterização do complexo de inclusão ropivacaína: β-ciclodextrina. Quimica Nova, 30(5), 1203-1207.