Characterization of the inflammatory infiltrate in peptic oesophagitis

A. Tozzi, A. Staiano, F. Paparo, E. Miele, M. Maglio, M. Di Meo, D. Simeone, R. Troncone

Research output: Contribution to journalArticle

Abstract

Background. The diagnosis of oesophagitis is mainly based on histology, but interpretation of endoscopic biopsies is often difficult. We performed immunohistochemical studies on oesophageal biopsies to see if better characterization of the inflammatory cell infiltrate would improve the accuracy of the histologic diagnosis of gastro-oesophageal reflux disease. Methods. The study groups consisted of 40 consecutive children (mean age ±SD: 79.6±51.9 months; 20 boys) with gastro-oesophageal reflux disease and 7 symptomatic children (mean age ±SD: 52.6±37.0 months; 3 boys) without gastro-oesophageal reflux disease. All patients underwent upper gastrointestinal endoscopy with oesophageal biopsies. The diagnosis of gastro-oesophageal reflux disease was established by conventional endoscopic and histologic criteria. In each mucosal biopsy specimen, the number of intraepithelial CD3+, CD25+ (IL2 receptor+), ICAM+, HLA-DR+ and mucosal mast cells were determined. Results. Conventional histology was in close agreement with endoscopic findings (p

Original languageEnglish
Pages (from-to)452-458
Number of pages7
JournalDigestive and Liver Disease
Volume33
Issue number6
Publication statusPublished - 2001

Keywords

  • Gastro-oesophageal reflux disease
  • Oesophageal eosinophils

ASJC Scopus subject areas

  • Gastroenterology

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    Tozzi, A., Staiano, A., Paparo, F., Miele, E., Maglio, M., Di Meo, M., Simeone, D., & Troncone, R. (2001). Characterization of the inflammatory infiltrate in peptic oesophagitis. Digestive and Liver Disease, 33(6), 452-458.