Abstract
Common variable immunodeficiency is characterized by an impairment in antibody production of at least two immunoglobulin isotypes, and abnormalities of both B and T cells have also been described. In this study, a profound alteration of the T cell receptor repertoire was noted, especially in CD8+ T cells, in CVID patients when compared to a control group. However, the higher number of oligoclonally expanded populations seen in the patient group was not dependent on age, whereas in the control group an age-related accumulation of these populations was noted. Expansion of CD8+ CD28- T cells in these patients is strongly correlated with T cell receptor repertoire restriction. Furthermore, analysis of cytokine production showed a statistically significant increase in IFN-γ secretion in the patient group. Lastly, CD94 and perforin were expressed at increased frequencies on CD8+ T cells in the patient group when compared to the control group. We speculate that these findings support the concept that CD8+ T cells may play an important regulatory role in CVID. (C) 2000 Academic Press.
| Original language | English |
|---|---|
| Pages (from-to) | 248-258 |
| Number of pages | 11 |
| Journal | Clinical Immunology |
| Volume | 97 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2000 |
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Keywords
- Clonal expansion
- Human
- Immunodeficiency disease
- Suppression
- T cell receptors
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Pathology and Forensic Medicine
Cite this
Characterization of the T cell receptor repertoire in patients with common variable immunodeficiency : Oligoclonal expansion of CD8+ T cells. / Serrano, Davide; Becker, Kai; Cunningham-Rundles, Charlotte; Mayer, Lloyd.
In: Clinical Immunology, Vol. 97, No. 3, 2000, p. 248-258.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Characterization of the T cell receptor repertoire in patients with common variable immunodeficiency
T2 - Oligoclonal expansion of CD8+ T cells
AU - Serrano, Davide
AU - Becker, Kai
AU - Cunningham-Rundles, Charlotte
AU - Mayer, Lloyd
PY - 2000
Y1 - 2000
N2 - Common variable immunodeficiency is characterized by an impairment in antibody production of at least two immunoglobulin isotypes, and abnormalities of both B and T cells have also been described. In this study, a profound alteration of the T cell receptor repertoire was noted, especially in CD8+ T cells, in CVID patients when compared to a control group. However, the higher number of oligoclonally expanded populations seen in the patient group was not dependent on age, whereas in the control group an age-related accumulation of these populations was noted. Expansion of CD8+ CD28- T cells in these patients is strongly correlated with T cell receptor repertoire restriction. Furthermore, analysis of cytokine production showed a statistically significant increase in IFN-γ secretion in the patient group. Lastly, CD94 and perforin were expressed at increased frequencies on CD8+ T cells in the patient group when compared to the control group. We speculate that these findings support the concept that CD8+ T cells may play an important regulatory role in CVID. (C) 2000 Academic Press.
AB - Common variable immunodeficiency is characterized by an impairment in antibody production of at least two immunoglobulin isotypes, and abnormalities of both B and T cells have also been described. In this study, a profound alteration of the T cell receptor repertoire was noted, especially in CD8+ T cells, in CVID patients when compared to a control group. However, the higher number of oligoclonally expanded populations seen in the patient group was not dependent on age, whereas in the control group an age-related accumulation of these populations was noted. Expansion of CD8+ CD28- T cells in these patients is strongly correlated with T cell receptor repertoire restriction. Furthermore, analysis of cytokine production showed a statistically significant increase in IFN-γ secretion in the patient group. Lastly, CD94 and perforin were expressed at increased frequencies on CD8+ T cells in the patient group when compared to the control group. We speculate that these findings support the concept that CD8+ T cells may play an important regulatory role in CVID. (C) 2000 Academic Press.
KW - Clonal expansion
KW - Human
KW - Immunodeficiency disease
KW - Suppression
KW - T cell receptors
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U2 - 10.1006/clim.2000.4941
DO - 10.1006/clim.2000.4941
M3 - Article
VL - 97
SP - 248
EP - 258
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 3
ER -