Charged lipid monolayers at the air-solution interface: Coupling to polyelectrolytes

F. Bordi, C. Cametti, F. De Luca, T. Gili, D. Gaudino, S. Sennato

Research output: Contribution to journalArticlepeer-review


The thermodynamic behaviour of mixed cationic-zwitterionic lipid mixtures dioleoyltrimethylammoniumpropane-dipalmitoylphosphatidylcholine (DOTAP-DPPC) at different mole fractions have been investigated by means of surface pressure measurements (Langmuir isotherms). Excess Gibbs energies of mixing have been calculated as a function of layer composition and surface pressure. Deviation from ideality evidences different molecular organisation of the two lipids, yielding the formation of cationic lipid domains in a zwitterionic lipid matrix. The stability of the mixed monolayer in the presence of both a simple electrolyte solution (NaCl) and a polyelectrolyte solution (NaPAA of different molecular weights) in the same charge ratio interval has been investigated and the influence of the polymer conformation briefly discussed.

Original languageEnglish
Pages (from-to)149-157
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Issue number2-3
Publication statusPublished - Jun 1 2003


  • Cationic-zwitterionic lipids
  • Gibbs energy
  • Polyelectrolytes

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces


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