TY - JOUR
T1 - Checkerboard reversal pattern and flash VEPs in dialysed and non-dialysed subjects
AU - Rossini, P. M.
AU - Pirchio, M.
AU - Treviso, M.
AU - Gambi, D.
AU - Di Paolo, B.
AU - Albertazzi, A.
PY - 1981
Y1 - 1981
N2 - In forty-three patients suffering from chronic renal failure (CRF; 32 non-dialysed, 11 dialysed) the flash VEP and the pattern VEP to different spatial (7.5′, 15′, 30′, 60′ checks) and temporal (2, 10, 20, 40 Hz) frequencies were investigated. Abnormally delayed flash VEPs were obtained in 53.6% of the cases; transient pattern VEPs had a delayed major positive deflection in 46% of the tested eyes and altered steady-state response in 58% with a total of 65% abnormal responses. Chronically dialysed subjects showed higher levels of altered VEPs for both the techniques. The shorter latencies normally observed with coarser checks in healthy people were maintained in CRF patients, resulting in an abnormal prolongation of the shift between high and low spatial frequencies. Higher statistical correlations linked the pattern VEP with blood urea nitrogen (P <0.001) and other renal chemistry than the flash VEP. These and other features could be ascribed to a specific involvement of a maculo-calcarine channel devoted to 'detailed' vision and suggest the usefulness of this method to provide a tool for the early detection of an encephalopathic uraemia.
AB - In forty-three patients suffering from chronic renal failure (CRF; 32 non-dialysed, 11 dialysed) the flash VEP and the pattern VEP to different spatial (7.5′, 15′, 30′, 60′ checks) and temporal (2, 10, 20, 40 Hz) frequencies were investigated. Abnormally delayed flash VEPs were obtained in 53.6% of the cases; transient pattern VEPs had a delayed major positive deflection in 46% of the tested eyes and altered steady-state response in 58% with a total of 65% abnormal responses. Chronically dialysed subjects showed higher levels of altered VEPs for both the techniques. The shorter latencies normally observed with coarser checks in healthy people were maintained in CRF patients, resulting in an abnormal prolongation of the shift between high and low spatial frequencies. Higher statistical correlations linked the pattern VEP with blood urea nitrogen (P <0.001) and other renal chemistry than the flash VEP. These and other features could be ascribed to a specific involvement of a maculo-calcarine channel devoted to 'detailed' vision and suggest the usefulness of this method to provide a tool for the early detection of an encephalopathic uraemia.
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U2 - 10.1016/0013-4694(81)90027-4
DO - 10.1016/0013-4694(81)90027-4
M3 - Article
C2 - 6171409
AN - SCOPUS:0019837330
VL - 52
SP - 435
EP - 444
JO - Electroencephalography and Clinical Neurophysiology
JF - Electroencephalography and Clinical Neurophysiology
SN - 0013-4694
IS - 5
ER -