Checkerboard reversal pattern and flash VEPs in dialysed and non-dialysed subjects

P. M. Rossini, M. Pirchio, M. Treviso, D. Gambi, B. Di Paolo, A. Albertazzi

Research output: Contribution to journalArticlepeer-review


In forty-three patients suffering from chronic renal failure (CRF; 32 non-dialysed, 11 dialysed) the flash VEP and the pattern VEP to different spatial (7.5′, 15′, 30′, 60′ checks) and temporal (2, 10, 20, 40 Hz) frequencies were investigated. Abnormally delayed flash VEPs were obtained in 53.6% of the cases; transient pattern VEPs had a delayed major positive deflection in 46% of the tested eyes and altered steady-state response in 58% with a total of 65% abnormal responses. Chronically dialysed subjects showed higher levels of altered VEPs for both the techniques. The shorter latencies normally observed with coarser checks in healthy people were maintained in CRF patients, resulting in an abnormal prolongation of the shift between high and low spatial frequencies. Higher statistical correlations linked the pattern VEP with blood urea nitrogen (P <0.001) and other renal chemistry than the flash VEP. These and other features could be ascribed to a specific involvement of a maculo-calcarine channel devoted to 'detailed' vision and suggest the usefulness of this method to provide a tool for the early detection of an encephalopathic uraemia.

Original languageEnglish
Pages (from-to)435-444
Number of pages10
JournalElectroencephalography and Clinical Neurophysiology
Issue number5
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


Dive into the research topics of 'Checkerboard reversal pattern and flash VEPs in dialysed and non-dialysed subjects'. Together they form a unique fingerprint.

Cite this