Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment

Cristina Albanesi, Claudia Scarponi, Sabatino Pallotta, Roberta Daniele, Daniela Bosisio, Stefania Madonna, Paola Fortugno, Safiyè Gonzalvo-Feo, Jean Denis Franssen, Marc Parmentier, Ornella De Pità, Giampiero Girolomoni, Silvano Sozzani

Research output: Contribution to journalArticle

Abstract

Psoriasis is a type I interferon-driven T cell-mediated disease characterized by the recruitment of plasmacytoid dendritic cells (pDC) into the skin. The molecules involved in pDC accumulation in psoriasis lesions are unknown. Chemerin is the only inflammatory chemo- tactic factor that is directly active on human blood pDC in vitro. The aim of this study was to evaluate the role of the chemerin/ChemR23 axis in the recruitment of pDC in psoriasis skin. Prepsoriatic skin adjacent to active lesions and early lesions were characterized by a strong expression of chemerin in the dermis and by the presence of CD15+ neutrophils and CD123+/BDCA-2 +/ChemR23+ pDC. Conversely, skin from chronic plaques showed low chemerin expression, segregation of neutrophils to epidermal microabscesses, and few pDC in the dermis. Chemerin expression was localized mainly in fibroblasts, mast cells, and endothelial cells. Fibroblasts cultured from skin of psoriatic lesions expressed higher levels of chemerin messenger RNA and protein than fibroblasts from uninvolved psoriatic skin or healthy donors and promoted pDC migration in vitro in a chemerin-dependent manner. Therefore, chemerin expression specifically marks the early phases of evolving skin psoriatic lesions and is temporally strictly associated with pDC. These results support a role for the chemerin/ChemR23 axis in the early phases of psoriasis development.

Original languageEnglish
Pages (from-to)249-258
Number of pages10
JournalJournal of Experimental Medicine
Volume206
Issue number1
DOIs
Publication statusPublished - Jan 16 2009

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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  • Cite this

    Albanesi, C., Scarponi, C., Pallotta, S., Daniele, R., Bosisio, D., Madonna, S., Fortugno, P., Gonzalvo-Feo, S., Franssen, J. D., Parmentier, M., De Pità, O., Girolomoni, G., & Sozzani, S. (2009). Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. Journal of Experimental Medicine, 206(1), 249-258. https://doi.org/10.1084/jem.20080129