Chemical composition and antifungal activity of Hypericum perforatum subsp. angustifolium roots from wild plants and plants grown under controlled conditions

N. Tocci, G. Simonetti, F. D. D'Auria, S. Panella, A. T. Palamara, F. Ferrari, G. Pasqua

Research output: Contribution to journalArticle

Abstract

The medicinal properties of the aerial parts of Hypericum perforatum subsp. angustifolium have been extensively investigated, yet little is known about the chemical composition or potential uses of the root extracts. In this study, xanthone production in wild plants and plants grown under controlled conditions was investigated. Chemical analyses carried out on wild plants revealed that xanthones were mainly accumulated in the roots. We mainly detected 1,7-dihydroxyxanthone, paxanthone, 5-O-methyl-2-deprenylrheediaxanthone B, kielcorin. The roots of wild plants showed low xanthone accumulation. In the roots of plants grown under controlled conditions, xanthone accumulation was 27 times greater than that in the roots of wild-grown plants. Kielcorin was not detected in the roots of plants grown under controlled conditions. As xanthones are known for their antifungal activity, the extracts from both samples were tested against the human fungal pathogens Candida albicans, non-albicansCandida species, Cryptococcus neoformans, and dermatophytes. The root extracts from plants grown under controlled conditions showed greater antifungal activity, probably correlated with higher xanthone accumulation.

Original languageEnglish
Pages (from-to)557-562
Number of pages6
JournalPlant Biosystems
Volume147
Issue number3
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Hypericum perforatum
wild plants
xanthone
chemical composition
xanthones
extracts
medicinal properties
Cryptococcus neoformans
keratinophilic fungi
wild plant
Candida albicans
aerial parts
pathogen
pathogens

Keywords

  • antifungal activity
  • Candida
  • Cryptococcus
  • dermatophytes
  • Hypericum
  • roots

ASJC Scopus subject areas

  • Plant Science
  • Ecology, Evolution, Behavior and Systematics

Cite this

Chemical composition and antifungal activity of Hypericum perforatum subsp. angustifolium roots from wild plants and plants grown under controlled conditions. / Tocci, N.; Simonetti, G.; D'Auria, F. D.; Panella, S.; Palamara, A. T.; Ferrari, F.; Pasqua, G.

In: Plant Biosystems, Vol. 147, No. 3, 09.2013, p. 557-562.

Research output: Contribution to journalArticle

Tocci, N. ; Simonetti, G. ; D'Auria, F. D. ; Panella, S. ; Palamara, A. T. ; Ferrari, F. ; Pasqua, G. / Chemical composition and antifungal activity of Hypericum perforatum subsp. angustifolium roots from wild plants and plants grown under controlled conditions. In: Plant Biosystems. 2013 ; Vol. 147, No. 3. pp. 557-562.
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