Chemical denervation produces supersensitivity of central serotonergic receptors involved in the control of TSH secretion in the rat

Gennaro Schettini, Gianfranco Di Renzo, Salvatore Amoroso, Lucio Annunziato, Aldo Quattrone

Research output: Contribution to journalArticle

Abstract

mChlorophenylpiperazine, a serotonin receptor agonist, produced dose-related decrease of TSH plasma levels in the rat. This effect was prevented by a pretreatment with metergoline, a serotonin receptor blocker. Chemical destruction of central serotonin pathways, induced by intraventricular injection of 5,7-dihydroxytryptamine, significantly increased the TSH-inhibiting effect of m-CPP. These findings suggest the possible development of supersensitivity of central serotonin receptors involved in the control of TSH secretion.

Original languageEnglish
Pages (from-to)349-352
Number of pages4
JournalBrain Research
Volume261
Issue number2
DOIs
Publication statusPublished - Feb 21 1983

Fingerprint

Metergoline
5,7-Dihydroxytryptamine
Intraventricular Injections
Serotonin Receptor Agonists
Serotonin Antagonists
Serotonin Receptors
Denervation
Serotonin
1-(3-chlorophenyl)piperazine

Keywords

  • 5,7-dihydroxytryptamine
  • m-cholorphhenylpiperazine
  • serotonin
  • supersensitivity of central 5-HT receptors
  • TSH

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Chemical denervation produces supersensitivity of central serotonergic receptors involved in the control of TSH secretion in the rat. / Schettini, Gennaro; Di Renzo, Gianfranco; Amoroso, Salvatore; Annunziato, Lucio; Quattrone, Aldo.

In: Brain Research, Vol. 261, No. 2, 21.02.1983, p. 349-352.

Research output: Contribution to journalArticle

Schettini, Gennaro ; Di Renzo, Gianfranco ; Amoroso, Salvatore ; Annunziato, Lucio ; Quattrone, Aldo. / Chemical denervation produces supersensitivity of central serotonergic receptors involved in the control of TSH secretion in the rat. In: Brain Research. 1983 ; Vol. 261, No. 2. pp. 349-352.
@article{59ab399249df41a7839b57160062b835,
title = "Chemical denervation produces supersensitivity of central serotonergic receptors involved in the control of TSH secretion in the rat",
abstract = "mChlorophenylpiperazine, a serotonin receptor agonist, produced dose-related decrease of TSH plasma levels in the rat. This effect was prevented by a pretreatment with metergoline, a serotonin receptor blocker. Chemical destruction of central serotonin pathways, induced by intraventricular injection of 5,7-dihydroxytryptamine, significantly increased the TSH-inhibiting effect of m-CPP. These findings suggest the possible development of supersensitivity of central serotonin receptors involved in the control of TSH secretion.",
keywords = "5,7-dihydroxytryptamine, m-cholorphhenylpiperazine, serotonin, supersensitivity of central 5-HT receptors, TSH",
author = "Gennaro Schettini and {Di Renzo}, Gianfranco and Salvatore Amoroso and Lucio Annunziato and Aldo Quattrone",
year = "1983",
month = "2",
day = "21",
doi = "10.1016/0006-8993(83)90643-1",
language = "English",
volume = "261",
pages = "349--352",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Chemical denervation produces supersensitivity of central serotonergic receptors involved in the control of TSH secretion in the rat

AU - Schettini, Gennaro

AU - Di Renzo, Gianfranco

AU - Amoroso, Salvatore

AU - Annunziato, Lucio

AU - Quattrone, Aldo

PY - 1983/2/21

Y1 - 1983/2/21

N2 - mChlorophenylpiperazine, a serotonin receptor agonist, produced dose-related decrease of TSH plasma levels in the rat. This effect was prevented by a pretreatment with metergoline, a serotonin receptor blocker. Chemical destruction of central serotonin pathways, induced by intraventricular injection of 5,7-dihydroxytryptamine, significantly increased the TSH-inhibiting effect of m-CPP. These findings suggest the possible development of supersensitivity of central serotonin receptors involved in the control of TSH secretion.

AB - mChlorophenylpiperazine, a serotonin receptor agonist, produced dose-related decrease of TSH plasma levels in the rat. This effect was prevented by a pretreatment with metergoline, a serotonin receptor blocker. Chemical destruction of central serotonin pathways, induced by intraventricular injection of 5,7-dihydroxytryptamine, significantly increased the TSH-inhibiting effect of m-CPP. These findings suggest the possible development of supersensitivity of central serotonin receptors involved in the control of TSH secretion.

KW - 5,7-dihydroxytryptamine

KW - m-cholorphhenylpiperazine

KW - serotonin

KW - supersensitivity of central 5-HT receptors

KW - TSH

UR - http://www.scopus.com/inward/record.url?scp=0020700105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020700105&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(83)90643-1

DO - 10.1016/0006-8993(83)90643-1

M3 - Article

C2 - 6831219

AN - SCOPUS:0020700105

VL - 261

SP - 349

EP - 352

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -