Chemical engineering approach to regenerative medicine

Giuseppe Perale, Filippo Rossi, Pietro Veglianese, Maurizio Masi

Research output: Contribution to journalArticle

Abstract

The intrinsically multi-factorial pathological trend of spinal cord injury is probably the most important reason behind the absence of efficient therapeutic strategies. Therefore, recent studies suggest the use of new tools combining the delivery of both cells and drugs. Systems which are able to perform multiple controlled delivery of different therapeutic agents have gained particularly strong interest. Hence, in order to avoid trial and error approaches, several studies were performed following the classic chemical engineering multiscale approach: tuning microchemistry to manipulate macro properties in order to satisfy specific medical needs as injectability, low stress on target tissues, ability to retain liquids, capability of carrying living cells, and possibility to control the delivery of drugs. In this framework we focused on injectable agarose-carbomer based hydrogels applying he results of our studies performed in the past two years: in vitro biocompatibility, physical chemical studies, drug delivery transport phenomena investigation, and in vivo biocompatibility in uninjured Brainbow mice.

Original languageEnglish
Pages (from-to)108-119
Number of pages12
JournalChemical Papers
Volume66
Issue number2
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Chemical Engineering
Regenerative Medicine
Chemical engineering
Biocompatibility
Microchemistry
Hydrogels
Drug and Narcotic Control
Drug delivery
Spinal Cord Injuries
Pharmaceutical Preparations
Sepharose
Macros
Tuning
Cells
Tissue
Injections
Liquids
Therapeutics
carbomer
In Vitro Techniques

Keywords

  • hydrogel
  • regenerative medicine
  • spinal cord injury repair

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Biochemistry
  • Industrial and Manufacturing Engineering
  • Materials Chemistry

Cite this

Chemical engineering approach to regenerative medicine. / Perale, Giuseppe; Rossi, Filippo; Veglianese, Pietro; Masi, Maurizio.

In: Chemical Papers, Vol. 66, No. 2, 02.2012, p. 108-119.

Research output: Contribution to journalArticle

Perale, Giuseppe ; Rossi, Filippo ; Veglianese, Pietro ; Masi, Maurizio. / Chemical engineering approach to regenerative medicine. In: Chemical Papers. 2012 ; Vol. 66, No. 2. pp. 108-119.
@article{ad38071ffb5649a98843c4bec9c46020,
title = "Chemical engineering approach to regenerative medicine",
abstract = "The intrinsically multi-factorial pathological trend of spinal cord injury is probably the most important reason behind the absence of efficient therapeutic strategies. Therefore, recent studies suggest the use of new tools combining the delivery of both cells and drugs. Systems which are able to perform multiple controlled delivery of different therapeutic agents have gained particularly strong interest. Hence, in order to avoid trial and error approaches, several studies were performed following the classic chemical engineering multiscale approach: tuning microchemistry to manipulate macro properties in order to satisfy specific medical needs as injectability, low stress on target tissues, ability to retain liquids, capability of carrying living cells, and possibility to control the delivery of drugs. In this framework we focused on injectable agarose-carbomer based hydrogels applying he results of our studies performed in the past two years: in vitro biocompatibility, physical chemical studies, drug delivery transport phenomena investigation, and in vivo biocompatibility in uninjured Brainbow mice.",
keywords = "hydrogel, regenerative medicine, spinal cord injury repair",
author = "Giuseppe Perale and Filippo Rossi and Pietro Veglianese and Maurizio Masi",
year = "2012",
month = "2",
doi = "10.2478/s11696-011-0111-5",
language = "English",
volume = "66",
pages = "108--119",
journal = "Chemical Papers",
issn = "0366-6352",
publisher = "Versita",
number = "2",

}

TY - JOUR

T1 - Chemical engineering approach to regenerative medicine

AU - Perale, Giuseppe

AU - Rossi, Filippo

AU - Veglianese, Pietro

AU - Masi, Maurizio

PY - 2012/2

Y1 - 2012/2

N2 - The intrinsically multi-factorial pathological trend of spinal cord injury is probably the most important reason behind the absence of efficient therapeutic strategies. Therefore, recent studies suggest the use of new tools combining the delivery of both cells and drugs. Systems which are able to perform multiple controlled delivery of different therapeutic agents have gained particularly strong interest. Hence, in order to avoid trial and error approaches, several studies were performed following the classic chemical engineering multiscale approach: tuning microchemistry to manipulate macro properties in order to satisfy specific medical needs as injectability, low stress on target tissues, ability to retain liquids, capability of carrying living cells, and possibility to control the delivery of drugs. In this framework we focused on injectable agarose-carbomer based hydrogels applying he results of our studies performed in the past two years: in vitro biocompatibility, physical chemical studies, drug delivery transport phenomena investigation, and in vivo biocompatibility in uninjured Brainbow mice.

AB - The intrinsically multi-factorial pathological trend of spinal cord injury is probably the most important reason behind the absence of efficient therapeutic strategies. Therefore, recent studies suggest the use of new tools combining the delivery of both cells and drugs. Systems which are able to perform multiple controlled delivery of different therapeutic agents have gained particularly strong interest. Hence, in order to avoid trial and error approaches, several studies were performed following the classic chemical engineering multiscale approach: tuning microchemistry to manipulate macro properties in order to satisfy specific medical needs as injectability, low stress on target tissues, ability to retain liquids, capability of carrying living cells, and possibility to control the delivery of drugs. In this framework we focused on injectable agarose-carbomer based hydrogels applying he results of our studies performed in the past two years: in vitro biocompatibility, physical chemical studies, drug delivery transport phenomena investigation, and in vivo biocompatibility in uninjured Brainbow mice.

KW - hydrogel

KW - regenerative medicine

KW - spinal cord injury repair

UR - http://www.scopus.com/inward/record.url?scp=83555168250&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=83555168250&partnerID=8YFLogxK

U2 - 10.2478/s11696-011-0111-5

DO - 10.2478/s11696-011-0111-5

M3 - Article

AN - SCOPUS:83555168250

VL - 66

SP - 108

EP - 119

JO - Chemical Papers

JF - Chemical Papers

SN - 0366-6352

IS - 2

ER -