Chemo-conization in early cervical cancer

Fabio Landoni, Gabriella Parma, Michele Peiretti, Vanna Zanagnolo, Mario Sideri, Nicoletta Colombo, Angelo Maggioni

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Objectives: The aim of the present study is to support the safety and feasibility of chemo-conization for early-stage cervical tumor in young patients wishing to preserve their fertility. Methods: Between October 2004 and November 2006, eleven patients were scheduled for conservative treatment. Subjects were selected for this treatment on the basis of favorable cervical tumors (<3 cm) and a desire to maintain fertility. All patients underwent neoadjuvant chemotherapy followed by conization or conization alone with pelvic lymphadenectomy. Obstetrical and oncologic outcomes were evaluated. Results and conclusions: The mean age of the eleven patients was 32 (range: 24-41), Figo Stage was IB1 in 8 cases and 3 cases were Stage IA2. Histological findings were squamous cell carcinoma in 5 patients and adenocarcinoma in 6 patients. Two patients were treated with TEP regimen every 3 weeks for three courses, while one patient had adjuvant chemotherapy with TEP. No recurrences were observed after a median follow-up of 20 months (range 7-29 months). Three pregnancies occurred during the follow-up period. Although the number is small, in selected patients this conservative approach seems to be feasible to cure early-stage cervical cancer therefore maintaining fertility.

Original languageEnglish
JournalGynecologic Oncology
Volume107
Issue number1 SUPPL.
DOIs
Publication statusPublished - Oct 2007

Fingerprint

Conization
Uterine Cervical Neoplasms
Fertility
Adjuvant Chemotherapy
Lymph Node Excision
Squamous Cell Carcinoma
Neoplasms
Adenocarcinoma
Safety
Recurrence
Drug Therapy
Pregnancy

Keywords

  • Cervical cancer
  • Chemo-conization
  • Fertility presentation

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Chemo-conization in early cervical cancer. / Landoni, Fabio; Parma, Gabriella; Peiretti, Michele; Zanagnolo, Vanna; Sideri, Mario; Colombo, Nicoletta; Maggioni, Angelo.

In: Gynecologic Oncology, Vol. 107, No. 1 SUPPL., 10.2007.

Research output: Contribution to journalArticle

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AU - Colombo, Nicoletta

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