Chemo-hormone therapy of non-well-differentiated endocrine tumours from different anatomic sites with cisplatinum, etoposide and slow release lanreotide formulation

P. Correale, A. Sciandivasci, C. Intrivici, A. Pascucci, M. T. Del Vecchio, S. Marsili, V. Savelli, L. Voltolini, M. Di Bisceglie, A. Guarnieri, G. Gotti, G. Francini

Research output: Contribution to journalArticle

Abstract

We report the results of a phase II trial in patients with metastatic endocrine tumours from different sites, which aimed to evaluate the anti-tumour activity and toxicity of a cisplatinum and etoposide regimen administered in combination with the somatostatin agonist lanreotide given in slow release formulation. Between January 1999 and November 2003, 27 patients with histological diagnoses of endocrine tumours with different degrees of differentiation, excluding well differentiated carcinoid neoplasms, received intravenous (i.v.) administration of cisplatinum (30 mg m-2) and etoposide (100 mg m-2) on days 1-3 and intramuscular administration of 60 mg lanreotide on day 1, in a 21-day cycle. All of the patients were evaluable for toxicity and response. The treatment was very well tolerated as no grade 4 toxicity was observed. Four patients achieved a complete response, six a partial response, 12 experienced disease stabilisation and five disease progression. The average time to progression and to survival were 9 and 24 months respectively. These results suggest that this chemo-hormone therapy regimen is well tolerated and active in patients with non-well differentiated endocrine tumours.

Original languageEnglish
Pages (from-to)1343-1347
Number of pages5
JournalBritish Journal of Cancer
Volume96
Issue number9
DOIs
Publication statusPublished - May 7 2007

Keywords

  • Chemotherapy
  • Hormonal manipulation
  • Neuroendocrine tumours

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Chemo-hormone therapy of non-well-differentiated endocrine tumours from different anatomic sites with cisplatinum, etoposide and slow release lanreotide formulation'. Together they form a unique fingerprint.

  • Cite this

    Correale, P., Sciandivasci, A., Intrivici, C., Pascucci, A., Del Vecchio, M. T., Marsili, S., Savelli, V., Voltolini, L., Di Bisceglie, M., Guarnieri, A., Gotti, G., & Francini, G. (2007). Chemo-hormone therapy of non-well-differentiated endocrine tumours from different anatomic sites with cisplatinum, etoposide and slow release lanreotide formulation. British Journal of Cancer, 96(9), 1343-1347. https://doi.org/10.1038/sj.bjc.6603734