TY - JOUR
T1 - Chemo-radiotherapy and autologous bone marrow transplantation in poor prognosis neuroblastoma
AU - Franzonel, P.
AU - Scarpati, D.
AU - Vitalel, V.
AU - Corvó, R.
AU - Barral, S.
AU - Guenzil, M.
AU - Orsattil, M.
AU - Dini, G.
PY - 1990
Y1 - 1990
N2 - In Genoa, 39 patients affected by disseminated neuroblastoma, one to twelve years old, were treated with intensive chemotherapy (Vincristine 4 mg/sqm c.i. over 5 days, Melphalan 140 mg/sqm), total body irradiation (TBI) (3.3 Gy for 3 days), and unpurged autologous bone marrow transplantation (ABMT) since October 1984 until November 1987. Thirty-two patients were in complete response (first group) and 7 had residual disease (second group) after an intensive chemotherapy induction regimen. Actuarial overall survival at 38 months is 52% and disease free survival at 30 months is 28% for the first group. Actuarial overall survival at 25 months is instead 14% for the second group related treatment toxicity has not been too high (3 deaths).
AB - In Genoa, 39 patients affected by disseminated neuroblastoma, one to twelve years old, were treated with intensive chemotherapy (Vincristine 4 mg/sqm c.i. over 5 days, Melphalan 140 mg/sqm), total body irradiation (TBI) (3.3 Gy for 3 days), and unpurged autologous bone marrow transplantation (ABMT) since October 1984 until November 1987. Thirty-two patients were in complete response (first group) and 7 had residual disease (second group) after an intensive chemotherapy induction regimen. Actuarial overall survival at 38 months is 52% and disease free survival at 30 months is 28% for the first group. Actuarial overall survival at 25 months is instead 14% for the second group related treatment toxicity has not been too high (3 deaths).
KW - Advanced neuroblastoma
KW - Autologous bone marrow transplantation
KW - Total body irradiation
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U2 - 10.1016/0167-8140(90)90185-Y
DO - 10.1016/0167-8140(90)90185-Y
M3 - Article
C2 - 2247630
AN - SCOPUS:0025655043
VL - 18
SP - 102
EP - 104
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
SN - 0167-8140
IS - SUPPL. 1
ER -