TY - JOUR
T1 - Chemoattractant receptors and leukocyte recruitment
T2 - More than cell migration
AU - Borroni, Elena Monica
AU - Bonecchi, Raffaella
AU - Mantovani, Alberto
AU - Locati, Massimo
PY - 2009/2/24
Y1 - 2009/2/24
N2 - Chemoattractants induce cell migration through the activation of a distinct family of structurally related heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors. Over the past few years, several receptors in this family have been identified that recognize different classes of chemoattractants but do not induce cell migration. These atypical "chemoattractant receptors" are unable to activate transduction events that lead directly to cell migration, but appear nonetheless to play a nonredundant role in leukocyte recruitment by shaping the chemoattractant gradient, either by removing, transporting, or concentrating their cognate ligands.
AB - Chemoattractants induce cell migration through the activation of a distinct family of structurally related heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors. Over the past few years, several receptors in this family have been identified that recognize different classes of chemoattractants but do not induce cell migration. These atypical "chemoattractant receptors" are unable to activate transduction events that lead directly to cell migration, but appear nonetheless to play a nonredundant role in leukocyte recruitment by shaping the chemoattractant gradient, either by removing, transporting, or concentrating their cognate ligands.
UR - http://www.scopus.com/inward/record.url?scp=66149119007&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66149119007&partnerID=8YFLogxK
U2 - 10.1126/scisignal.259pe10
DO - 10.1126/scisignal.259pe10
M3 - Article
C2 - 19244210
AN - SCOPUS:66149119007
VL - 2
JO - Science Signaling
JF - Science Signaling
SN - 1937-9145
IS - 59
ER -