Chemoembolization in colorectal liver metastases: The rebirth

Giammaria Fiorentini, Camillo Aliberti, Luca Mulazzani, Paolo Coschiera, Vincenzo Catalano, David Rossi, Paolo Giordani, Stefano Ricci

Research output: Contribution to journalArticle

Abstract

Currently image-guided trans-arterial chemoembolization (TACE) has a significant role in the therapy of patients with hepatocellular carcinoma and liver metastases. This endovascular hepatic-directed therapy offers the dual benefit of true local neoplastic control and reduction of side-effects. As a result, it has been included in the guidelines for primary liver cancer and is often considered as salvage therapy for patients liver metastases from neuroendocrine and chemorefractory colorectal tumors. The development of new embolizing agents, such as DC beads loaded with doxorubicin and irinotecan, permits better standardization and definition of protocols, making the procedures less linked to criteria of different hospitals and personal experiences of interventional radiologists. The understanding that hypoxia induces vessel regrowth will open a new avenue for clinical research and a rebirth for TACE. Chemoembolization followed by target therapy (bevacizumab, aflibercept and regorafenib) could increase quality, duration of responses and better quality of life.

Original languageEnglish
Pages (from-to)575-584
Number of pages10
JournalAnticancer Research
Volume34
Issue number2
Publication statusPublished - Feb 1 2014

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Keywords

  • Aflibercept
  • Cetuximab
  • Chemoembolization
  • Colorectal cancer
  • DEBIRI
  • Drug-eluting beads
  • Irinotecan
  • KRAS
  • Liver metastases
  • Regorafenib
  • Review

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Fiorentini, G., Aliberti, C., Mulazzani, L., Coschiera, P., Catalano, V., Rossi, D., Giordani, P., & Ricci, S. (2014). Chemoembolization in colorectal liver metastases: The rebirth. Anticancer Research, 34(2), 575-584.