TY - JOUR
T1 - Chemoembolization in Conjunction with Bevacizumab
T2 - Preliminary Results
AU - Fiorentini, Giammaria
AU - Sarti, Donatella
AU - Aliberti, Camillo
AU - Carandina, Riccardo
AU - Mulazzani, Luca
AU - Felicioli, Alessandro
AU - Guadagni, Stefano
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Transarterial chemoembolization is an effective, minimally invasive therapy that is widely used for treatment of unresectable colorectal cancer liver metastases (CRC-LM). However, chemoembolization induces a hypoxic microenvironment, which increases neoangiogenesis and may promote early progression. For this reason, transarterial chemoembolization efficacy may be improved by combining it with an angiogenesis inhibitor, such as bevacizumab. This report shows that transarterial chemoembolization with irinotecan-loaded polyethylene glycol embolics and bevacizumab therapy was effective and well tolerated by 6 patients with CRC-LM, resulting in a disease control rate of 83% and an overall improvement in quality of life.
AB - Transarterial chemoembolization is an effective, minimally invasive therapy that is widely used for treatment of unresectable colorectal cancer liver metastases (CRC-LM). However, chemoembolization induces a hypoxic microenvironment, which increases neoangiogenesis and may promote early progression. For this reason, transarterial chemoembolization efficacy may be improved by combining it with an angiogenesis inhibitor, such as bevacizumab. This report shows that transarterial chemoembolization with irinotecan-loaded polyethylene glycol embolics and bevacizumab therapy was effective and well tolerated by 6 patients with CRC-LM, resulting in a disease control rate of 83% and an overall improvement in quality of life.
UR - http://www.scopus.com/inward/record.url?scp=85051929426&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051929426&partnerID=8YFLogxK
U2 - 10.1016/j.jvir.2018.04.022
DO - 10.1016/j.jvir.2018.04.022
M3 - Article
C2 - 30146190
AN - SCOPUS:85051929426
VL - 29
SP - 1236
EP - 1239
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
SN - 1051-0443
IS - 9
ER -