Chemokine and chemokine receptors in autoimmunity: the case of primary biliary cholangitis

Jinjung Choi, Carlo Selmi, Patrick S C Leung, Thomas P. Kenny, Tania Roskams, M. Eric Gershwin

Research output: Contribution to journalArticle

Abstract

Chemokines represent a major mediator of innate immunity and play a key role in the selective recruitment of cells during localized inflammatory responses. Beyond critical extracellular mediators of leukocyte trafficking, chemokines and their cognate receptors are expressed by a variety of resident and infiltrating cells (monocytes, lymphocytes, NK cells, mast cells, and NKT cells). Chemokines represent ideal candidates for mechanistic studies (particularly in murine models) to better understand the pathogenesis of chronic inflammation and possibly become biomarkers of disease. Nonetheless, therapeutic approaches targeting chemokines have led to unsatisfactory results in rheumatoid arthritis, while biologics against pro-inflammatory cytokines are being used worldwide with success. In this comprehensive review we will discuss the evidence supporting the involvement of chemokines and their specific receptors in mediating the effector cell response, utilizing the autoimmune/primary biliary cholangitis setting as a paradigm.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalExpert Review of Clinical Immunology
DOIs
Publication statusAccepted/In press - Feb 26 2016

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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