Abstract
Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation of specific T-cell responses and for the development of immune tolerance. Immature DCs reside in peripheral tissues and specialize in antigen capture, whereas mature DCs reside mostly in the secondary lymphoid organs where they act as antigen-presenting cells. The correct localization of DCs is strictly regulated by a large variety of chemotactic and nonchemotactic signals that include bacterial products, DAMPs (danger-associated molecular patterns), complement proteins, lipids, and chemokines. These signals function both individually and in concert, generating a complex regulatory network. This network is regulated at multiple levels through different strategies, such as synergistic interactions, proteolytic processing, and the actions of atypical chemokine receptors. Understanding this complex scenario will help to clarify the role of DCs in different pathological conditions, such as autoimmune diseases and cancers and will uncover new molecular targets for therapeutic interventions.
| Original language | English |
|---|---|
| Article number | 5 |
| Journal | Cellular and Molecular Immunology |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 1 2018 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases
Cite this
Chemokine and chemotactic signals in dendritic cell migration review-article. / Del Prete, Annalisa; Tiberio, Laura; Schioppa, Tiziana; Sozio, Francesca; Bosisio, Daniela; Sozzani, Silvano.
In: Cellular and Molecular Immunology, Vol. 15, No. 4, 5, 01.04.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Chemokine and chemotactic signals in dendritic cell migration review-article
AU - Del Prete, Annalisa
AU - Tiberio, Laura
AU - Schioppa, Tiziana
AU - Sozio, Francesca
AU - Bosisio, Daniela
AU - Sozzani, Silvano
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation of specific T-cell responses and for the development of immune tolerance. Immature DCs reside in peripheral tissues and specialize in antigen capture, whereas mature DCs reside mostly in the secondary lymphoid organs where they act as antigen-presenting cells. The correct localization of DCs is strictly regulated by a large variety of chemotactic and nonchemotactic signals that include bacterial products, DAMPs (danger-associated molecular patterns), complement proteins, lipids, and chemokines. These signals function both individually and in concert, generating a complex regulatory network. This network is regulated at multiple levels through different strategies, such as synergistic interactions, proteolytic processing, and the actions of atypical chemokine receptors. Understanding this complex scenario will help to clarify the role of DCs in different pathological conditions, such as autoimmune diseases and cancers and will uncover new molecular targets for therapeutic interventions.
AB - Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation of specific T-cell responses and for the development of immune tolerance. Immature DCs reside in peripheral tissues and specialize in antigen capture, whereas mature DCs reside mostly in the secondary lymphoid organs where they act as antigen-presenting cells. The correct localization of DCs is strictly regulated by a large variety of chemotactic and nonchemotactic signals that include bacterial products, DAMPs (danger-associated molecular patterns), complement proteins, lipids, and chemokines. These signals function both individually and in concert, generating a complex regulatory network. This network is regulated at multiple levels through different strategies, such as synergistic interactions, proteolytic processing, and the actions of atypical chemokine receptors. Understanding this complex scenario will help to clarify the role of DCs in different pathological conditions, such as autoimmune diseases and cancers and will uncover new molecular targets for therapeutic interventions.
UR - http://www.scopus.com/inward/record.url?scp=85044249737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044249737&partnerID=8YFLogxK
U2 - 10.1038/s41423-018-0005-3
DO - 10.1038/s41423-018-0005-3
M3 - Review article
AN - SCOPUS:85044249737
VL - 15
JO - Cellular and Molecular Immunology
JF - Cellular and Molecular Immunology
SN - 1672-7681
IS - 4
M1 - 5
ER -