Chemokine and chemotactic signals in dendritic cell migration review-article

Annalisa Del Prete, Laura Tiberio, Tiziana Schioppa, Francesca Sozio, Daniela Bosisio, Silvano Sozzani

Research output: Contribution to journalReview articlepeer-review

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation of specific T-cell responses and for the development of immune tolerance. Immature DCs reside in peripheral tissues and specialize in antigen capture, whereas mature DCs reside mostly in the secondary lymphoid organs where they act as antigen-presenting cells. The correct localization of DCs is strictly regulated by a large variety of chemotactic and nonchemotactic signals that include bacterial products, DAMPs (danger-associated molecular patterns), complement proteins, lipids, and chemokines. These signals function both individually and in concert, generating a complex regulatory network. This network is regulated at multiple levels through different strategies, such as synergistic interactions, proteolytic processing, and the actions of atypical chemokine receptors. Understanding this complex scenario will help to clarify the role of DCs in different pathological conditions, such as autoimmune diseases and cancers and will uncover new molecular targets for therapeutic interventions.

Original languageEnglish
Article number5
JournalCellular and Molecular Immunology
Volume15
Issue number4
DOIs
Publication statusPublished - Apr 1 2018

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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